Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation.
- Ma B School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China; Renji Hospital Clinical Stem Cell Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
- Hottiger MO Department of Molecular Mechanisms of Disease, University of Zurich , Zurich , Switzerland.
- 2016-10-08
Published in:
- Frontiers in immunology. - 2016
English
Besides its important role in embryonic development and homeostatic self-renewal in adult tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory functions. This is, at least partially, due to either repressing or enhancing the NF-κB pathway. Similarly, the NF-κB pathway either positively or negatively regulates Wnt/β-catenin signaling. Different components of the two pathways are involved in this crosstalk, forming a complex regulatory network. This review summarizes our current understanding of the molecular mechanisms underlying the cross-regulation between the two pathways and discusses their involvement in inflammation and inflammation-associated diseases such as cancer.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.3389/fimmu.2016.00378
- PMID 27713747
- Persistent URL
- https://sonar.ch/global/documents/236616
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