Journal article
A Gut Feeling about C9ORF72.
- Polymenidou M Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. Electronic address: magdalini.polymenidou@uzh.ch.
- 2020-08-18
Published in:
- Trends in immunology. - 2020
Amyotrophic Lateral Sclerosis
Animals
Bacteria
C9orf72 Protein
Frontotemporal Dementia
Humans
Inflammation
Mice
English
C9ORF72 mutations are the most common genetic cause of ALS and FTD, leading to neurodegeneration via complex mechanisms. Mutations also lead to loss of C9ORF72 function and inflammatory diseases in patients and knockout mice. Burberry et al. now show that C9orf72-associated inflammation and premature death in mice are directly modified by the gut microbiome.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.it.2020.07.012
- PMID 32800706
- Persistent URL
- https://sonar.ch/global/documents/237413
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