Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.
- Aichele P Department of Pathology, University of Zürich, Switzerland.
- Kyburz D
- Ohashi PS
- Odermatt B
- Zinkernagel RM
- Hengartner H
- Pircher H
- 1994-01-18
Published in:
- Proceedings of the National Academy of Sciences of the United States of America. - 1994
Amino Acid Sequence
Animals
Autoimmune Diseases
Diabetes Mellitus, Experimental
Disease Models, Animal
Immune Tolerance
Immunization
Immunodominant Epitopes
Islets of Langerhans
Lymphocytic Choriomeningitis
Lymphocytic choriomeningitis virus
Mice
Mice, Inbred C57BL
Mice, Transgenic
Molecular Sequence Data
Oligopeptides
T-Lymphocytes, Cytotoxic
Viral Proteins
English
A synthetic peptide corresponding to an immunodominant epitope of lymphocytic choriomeningitis virus glycoprotein (LCMV GP) was used to prime or to tolerize CD8+ T cells in vivo, dependent on mode of immunization. Peptide-specific tolerance was then examined in transgenic mice expressing LCMV GP in the beta islet cells of the pancreas; these mice develop CD8+ T-cell-mediated diabetes within 8-14 days after LCMV infection. Specific peptide-induced tolerance prevented autoimmune destruction of beta islet cells and diabetes in this transgenic mouse model.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1073/pnas.91.2.444
- PMID 8290546
- Persistent URL
- https://sonar.ch/global/documents/237702
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