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Evaluation of tools for annual capture of adherence to immunosuppressive medications after renal transplantation - a single-centre open prospective trial.

  • Gustavsen MT Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • Midtvedt K Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • Lønning K Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • Jacobsen T School of Pharmacy, University of Oslo, Oslo, Norway.
  • Reisaeter AV Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • De Geest S Institute of Nursing Science, University of Basel, Basel, Switzerland.
  • Andersen MH Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • Hartmann A Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • Åsberg A Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
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  • 2019-02-17
Published in:
  • Transplant international : official journal of the European Society for Organ Transplantation. - 2019
Basel Assessment of Adherence to Immunosuppressive Medication Scale
adherence
clinician's score
tacrolimus variability
Adult
Aged
Biopsy
Cross-Sectional Studies
Data Collection
Drug Administration Schedule
Female
Graft Rejection
Humans
Immunosuppressive Agents
Kidney Failure, Chronic
Kidney Transplantation
Male
Medication Adherence
Middle Aged
Norway
Prospective Studies
Registries
Risk Factors
Self Report
Surveys and Questionnaires
Transplant Recipients
Treatment Outcome
English Annual assessment of adherence would strengthen long-term outcome assessments from registry data. The objective of this study was to evaluate tools suitable for annual routine capture of adherence data in renal transplant recipients. A single-centre open prospective trial included 295 renal transplant recipients on tacrolimus. Two-thirds of the patients were included 4 weeks post-transplant, randomized 1:1 to intensive or single-point adherence assessment in the early phase and 1-year post-transplant. One-third were included 1-year post-transplant during a cross-sectional investigation. Adherence was assessed using multiple methods: The "Basel Assessment of Adherence to Immunosuppressive Medication Scale" (BAASIS© ) questionnaire was used to assess self-reported adherence. The treating clinician scored patient's adherence and tacrolimus trough-concentration variability was calculated. In the analyses, the data from the different tools were dichotomized (adherent/nonadherent). The BAASIS© overall response rate was over 80%. Intensive BAASIS© assessment early after transplantation increased the chance of capturing a nonadherence event, but did not influence the 1-year adherence prevalence. The adherence tools generally captured different populations. Combining the tools, the nonadherence prevalence at 1 year was 38%. The different tools identified to a large degree different patients as nonadherent. Combining these tools is feasible for annual capture of adherence status.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/238028
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