Journal article
LATS1-Beclin1 mediates a non-canonical connection between the Hippo pathway and autophagy.
- Tang F Department of Biomedicine, University of Basel, Basel, Switzerland.
- Christofori G Department of Biomedicine, University of Basel, Basel, Switzerland.
- 2020-09-18
Published in:
- Molecular & cellular oncology. - 2020
English
Understanding the mechanisms of evasive resistance in cancer is of great importance to develop efficient therapies. Analyzing the molecular mechanisms underlying therapy resistance of hepatocellular carcinoma (HCC), we have discovered a kinase-activity independent role of LATS1 (large tumor suppressor) but not LATS2 in regulating sorafenib-induced lethal autophagy in HCC. We have found that the autophagy regulatory role of LATS1 is a general phenomenon in response to various stimuli of autophagy induction which relies on a LATS1-specific protein domain. Mechanistically, the autophagy regulatory role of LATS1 is coupled with Beclin-1 (BECN1) K27-linked ubiquitination and BECN1 self-dimerization. Our study highlights a LATS1-mediated non-classical interaction between the Hippo signaling pathway and autophagy in therapy response and carcinogenesis.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1080/23723556.2020.1757378
- PMID 32944618
- Persistent URL
- https://sonar.ch/global/documents/238299
Statistics
Document views: 27
File downloads: