Journal article
Reusable bi-directional 3ω sensor to measure thermal conductivity of 100-μm thick biological tissues.
- Lubner SD Mechanical Engineering, University of California, Berkeley, Berkeley, California 94720, USA.
- Choi J Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.
- Wehmeyer G Mechanical Engineering, University of California, Berkeley, Berkeley, California 94720, USA.
- Waag B Mechanical Engineering, ETH Zurich, Zurich 8092, Switzerland.
- Mishra V Mechanical Engineering, University of California, Berkeley, Berkeley, California 94720, USA.
- Natesan H Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.
- Bischof JC Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.
- Dames C Mechanical Engineering, University of California, Berkeley, Berkeley, California 94720, USA.
- 2015-02-02
Published in:
- The Review of scientific instruments. - 2015
Animals
Computer Simulation
Electrical Equipment and Supplies
Ice
Liver
Mice
Models, Biological
Temperature
Thermal Conductivity
Water
English
Accurate knowledge of the thermal conductivity (k) of biological tissues is important for cryopreservation, thermal ablation, and cryosurgery. Here, we adapt the 3ω method-widely used for rigid, inorganic solids-as a reusable sensor to measure k of soft biological samples two orders of magnitude thinner than conventional tissue characterization methods. Analytical and numerical studies quantify the error of the commonly used "boundary mismatch approximation" of the bi-directional 3ω geometry, confirm that the generalized slope method is exact in the low-frequency limit, and bound its error for finite frequencies. The bi-directional 3ω measurement device is validated using control experiments to within ±2% (liquid water, standard deviation) and ±5% (ice). Measurements of mouse liver cover a temperature ranging from -69 °C to +33 °C. The liver results are independent of sample thicknesses from 3 mm down to 100 μm and agree with available literature for non-mouse liver to within the measurement scatter.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1063/1.4905680
- PMID 25638111
- Persistent URL
- https://sonar.ch/global/documents/238618
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