Back
Full-text
Journal article

The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasis.

  • Spalinger MR Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
  • Scharl M Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
  • 2016-07-13
Published in:
  • United European gastroenterology journal. - 2016
Crohn’s disease
Inflammatory bowel disease
PTPN22
adaptive immunity
innate immunity
ulcerative colitis
English Inflammatory bowel disease represents a chronic intestinal inflammation. Recent knowledge suggests a crucial role for genetic, immunological and bacterial factors in inflammatory bowel disease pathogenesis. Variations within the gene locus encoding PTPN22 have been associated with inflammatory bowel disease. PTPN22 is critically involved in controlling immune cell activation and thereby plays an important role in maintaining intestinal homeostasis. Although in B and T cells the mechanism showing how PTPN22 affects cell signalling pathways is well studied, its role in myeloid cells remains less defined. Regulation of the innate immune system plays an essential role in the intestine, and levels of PTPN22 in myeloid cells are drastically reduced in the intestine of inflammatory bowel disease patients. Therefore, additional studies to define the role of PTPN22 in myeloid cells might clearly enhance our understanding of how PTPN22 contributes to intestinal homeostasis.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/23938
Statistics
Document views: 32 File downloads:
  • Full-text: 0