Back
The Coupled Chemical and Physical Dynamics Model of MALDI.
Journal article

The Coupled Chemical and Physical Dynamics Model of MALDI.

  • Knochenmuss R Departement für Chemie und Biochemie, Universität Bern, CH-3012 Bern, Switzerland; email: rknochenmuss@gmx.net.
  • 2016-04-13
Published in:
  • Annual review of analytical chemistry (Palo Alto, Calif.). - 2016
MALDI
coupled physical and chemical dynamics model
exciton pooling
ion-molecule reactions
ionization mechanisms
English The coupled physical and chemical dynamics model of ultraviolet matrix-assisted laser desorption/ionization (MALDI) has reproduced and explained a wide variety of MALDI phenomena. The rationale behind and elements of the model are reviewed, including the photophysics, kinetics, and thermodynamics of primary and secondary reaction steps. Experimental results are compared with model predictions to illustrate the foundations of the model, coupling of ablation and ionization, differences between and commonalities of matrices, secondary charge transfer reactions, ionization in both polarities, fluence and concentration dependencies, and suppression and enhancement effects.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/239712
Statistics
Document views: 16 File downloads: