A surface-based approach to quantify local cortical gyrification.

Schaer M; Cuadra MB; Tamarit L; Lazeyras F; Eliez S; Thiran JP

doi:10.1109/TMI.2007.903576

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Journal article

A surface-based approach to quantify local cortical gyrification.

Schaer M Service Médico-Pédagogique, Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland. marie.schaer@medecine.unige.ch
Cuadra MB
Tamarit L
Lazeyras F
Eliez S
Thiran JP

2008-03-13

Published in:

IEEE transactions on medical imaging. - 2008

Image Interpretation, Computer-Assisted

Pattern Recognition, Automated

English The high complexity of cortical convolutions in humans is very challenging both for engineers to measure and compare it, and for biologists and physicians to understand it. In this paper, we propose a surface-based method for the quantification of cortical gyrification. Our method uses accurate 3-D cortical reconstruction and computes local measurements of gyrification at thousands of points over the whole cortical surface. The potential of our method to identify and localize precisely gyral abnormalities is illustrated by a clinical study on a group of children affected by 22q11 Deletion Syndrome, compared to control individuals.

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