Progesterone Resistance in Endometriosis: an Acquired Property?

McKinnon B; Mueller M; Montgomery G

doi:10.1016/j.tem.2018.05.006

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Journal article

Progesterone Resistance in Endometriosis: an Acquired Property?

McKinnon B Department of Gynecology and Obstetrics, Frauenklinik, Inselspital Bern, Switzerland. Electronic address: brett.mckinnon@dkf.unibe.ch.
Mueller M Department of Gynecology and Obstetrics, Frauenklinik, Inselspital Bern, Switzerland.
Montgomery G Genomics of Reproductive Disorders, Institute for Molecular Bioscience, University of Queensland, Australia.

2018-06-24

Published in:

Trends in endocrinology and metabolism: TEM. - 2018

English Endometriosis is the growth of endometrial tissue outside the uterus and is characterized by progesterone resistance and changes in global and progesterone target gene expression. However, the mechanism behind this and whether it is innate, acquired, or present in both the eutopic and ectopic tissue in not always clear. We find large-scale gene expression studies in eutopic tissue, indicative of progesterone resistance, are often contradictory, potentially due to the dynamic nature of this tissue, whereas suppressed progesterone receptor expression is supported in ectopic but not eutopic tissue. This suggests more studies are required in eutopic tissue particularly, and that potentially the suppressed progesterone receptor (PR) expression is a consequence of the pathogenic process and exposure to the peritoneal environment.

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