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The Ultimaster Biodegradable-Polymer Sirolimus-Eluting Stent: An Updated Review of Clinical Evidence.

  • Chisari A Division of Cardiology, Santa Corona Hospital, Via XXV Aprile, 38, Pietra Ligure 17027, Italy. albertochisari@yahoo.it.
  • Pistritto AM Division of Cardiology, San Paolo Hospital, Savona 17100, Italy. annamariapistritto@hotmail.it.
  • Piccolo R Department of Cardiology, Bern University Hospital, University of Bern, Bern 3010, Switzerland. Raffaele.Piccolo@insel.ch.
  • La Manna A Cardiovascular Department, Ferrarotto Hospital, University of Catania, Catania 95124, Italy. lamanna.cardio@gmail.com.
  • Danzi GB Division of Cardiology, Santa Corona Hospital, Via XXV Aprile, 38, Pietra Ligure 17027, Italy. gbdanzi@tin.it.
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  • 2016-09-09
Published in:
  • International journal of molecular sciences. - 2016
Ultimaster stent
biodegradable polymer drug eluting stent
coronary stent
new-generation DES
sirolimus-eluting stent
Angioplasty, Balloon
Biodegradable Plastics
Clinical Trials, Phase I as Topic
Clinical Trials, Phase II as Topic
Drug-Eluting Stents
Humans
Sirolimus
English The Ultimaster coronary stent system (Terumo Corporation, Tokyo, Japan) represents a new iteration in drug-eluting stent (DES) technology that has recently received the Conformité Européenne (CE) mark approval for clinical use. The Ultimaster is a thin-strut, cobalt chromium, biodegradable-polymer, sirolimus-eluting coronary stent. The high elasticity of the biodegradable-polymer (PDLLA-PCL) and the abluminal gradient coating technology are additional novel features of this coronary device. The Ultimaster DES has undergone extensive clinical evaluation in two studies: The CENTURY I and II trials. Results from these two landmark studies suggested an excellent efficacy and safety profile of the Ultimaster DES across several lesion and patient subsets, with similar clinical outcomes to contemporary, new-generation DES. The aim of this review is to summarize the rationale behind this novel DES technology and to provide an update of available evidence about the clinical performance of the Ultimaster DES.
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  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/241766
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