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Novel concepts in plasmacytoid dendritic cell (pDC) development and differentiation.
Journal article

Novel concepts in plasmacytoid dendritic cell (pDC) development and differentiation.

  • Rodrigues PF Department of Biomedicine, University of Basel, 4058, Basel, Switzerland.
  • Tussiwand R Department of Biomedicine, University of Basel, 4058, Basel, Switzerland; Laboratory of Immune Regulation, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: roxane.tussiwand@nih.gov.
  • 2020-08-03
Published in:
  • Molecular immunology. - 2020
Development
Hematopoiesis
Lymphoid
Myeloid
pDC
Animals
Cell Differentiation
Cell Lineage
Dendritic Cells
Humans
Lymphoid Progenitor Cells
Myeloid Progenitor Cells
English Plasmacytoid dendritic cells (pDCs) are an immune subset specialized in the production of Type I Interferons (IFNs). They are characterized by co-expression of myeloid and lymphoid markers. Their developmental origin has been studied since their discovery and the identification of a myeloid progenitor capable of generating all dendritic cell (DC) subsets, including pDCs, led to their classification within the myeloid compartment. However, recent findings challenge this hypothesis and provide evidence for a lymphoid origin for the majority of pDCs 46-48. In this review we discuss and present the original myeloid and the newer lymphoid developmental trajectories of pDCs.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/242205
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