Journal article
Complementary DNA cloning of complement C8 beta and its sequence homology to C9.
- Haefliger JA Institut de Biochimie, Université de Lausanne, Epalinges, Switzerland.
- Tschopp J
- Nardelli D
- Wahli W
- Kocher HP
- Tosi M
- Stanley KK
- 1987-06-16
Published in:
- Biochemistry. - 1987
Amino Acid Sequence
Base Sequence
Cloning, Molecular
Complement C8
Complement C9
DNA
Humans
Liver
Macromolecular Substances
Sequence Homology, Nucleic Acid
English
The complete amino acid sequence of mature C8 beta has been derived from the DNA sequence of a cDNA clone identified by expression screening of a human liver cDNA library. Comparison with the amino acid sequence of C9 shows an overall homology with few deletions and insertions. In particular, the cysteine-rich domains and membrane-inserting regions of C9 are well conserved. These findings are discussed in relation to a possible mechanism of membrane attack complex formation.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1021/bi00386a045
- PMID 3651397
- Persistent URL
- https://sonar.ch/global/documents/242413
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