Complementary DNA cloning of complement C8 beta and its sequence homology to C9.

Haefliger JA; Tschopp J; Nardelli D; Wahli W; Kocher HP; Tosi M; Stanley KK

doi:10.1021/bi00386a045

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Complementary DNA cloning of complement C8 beta and its sequence homology to C9.

Haefliger JA Institut de Biochimie, Université de Lausanne, Epalinges, Switzerland.
Tschopp J
Nardelli D
Wahli W
Kocher HP
Tosi M
Stanley KK

1987-06-16

Published in:

Biochemistry. - 1987

Sequence Homology, Nucleic Acid

English The complete amino acid sequence of mature C8 beta has been derived from the DNA sequence of a cDNA clone identified by expression screening of a human liver cDNA library. Comparison with the amino acid sequence of C9 shows an overall homology with few deletions and insertions. In particular, the cysteine-rich domains and membrane-inserting regions of C9 are well conserved. These findings are discussed in relation to a possible mechanism of membrane attack complex formation.

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