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Cellulose nanocrystals: a multimodal tool to enhance the targeted drug delivery against bone disorders
Journal article

Cellulose nanocrystals: a multimodal tool to enhance the targeted drug delivery against bone disorders

  • Zoia, Luca Department of Earth & Environmental Science, University of Milano-Bicocca, Piazza della Scienza 1, 20126, Milano, Italy
  • Morelli, Annalisa Department of Molecular Biochemistry & Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milano, Italy
  • Talamini, Laura Department of Molecular Biochemistry & Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milano, Italy
  • Violatto, Martina B Department of Molecular Biochemistry & Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milano, Italy
  • Lovati, Arianna B IRCCS Istituto Ortopedico Galeazzi, Cell & Tissue Engineering Laboratory, Via Riccardo Galeazzi 4, 20161, Milano, Italy
  • Lopa, Silvia IRCCS Istituto Ortopedico Galeazzi, Cell & Tissue Engineering Laboratory, Via Riccardo Galeazzi 4, 20161, Milano, Italy
  • Recordati, Camilla Department of Veterinary Medicine, University of Milano, Via dell'Università 6, 26900, Lodi, Italy
  • Toffanin, Chiara Department of Molecular Biochemistry & Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milano, Italy
  • Salanti, Anika Department of Earth & Environmental Science, University of Milano-Bicocca, Piazza della Scienza 1, 20126, Milano, Italy
  • Russo, Luca Department of Molecular Biochemistry & Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milano, Italy
  • Colombo, Laura Department of Molecular Biochemistry & Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milano, Italy
  • Moretti, Matteo Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Via Tesserete 46, 6900, Lugano, Switzerland
  • Salmona, Mario Department of Molecular Biochemistry & Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milano, Italy
  • Ferla, Barbara La Department of Biotechnology & Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milano, Italy
  • Bigini, Paolo ORCID Department of Molecular Biochemistry & Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milano, Italy
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Published in:
  • Nanomedicine. - Future Medicine Ltd. - 2020, vol. 15, no. 23, p. 2271-2285
Development
General Materials Science
Medicine (miscellaneous)
Bioengineering
Biomedical Engineering
English Aim: We investigated the use of cellulose nanocrystals (CNCs) as drug nanocarriers combining an anti-osteoporotic agent, alendronate (ALN), and an anti-cancer drug, doxorubicin (DOX). Materials & methods: CNC physicochemical characterization, in vivo imaging coupled with histology and  in vitro uptake and toxicity assays were carried out. Results: In vivo CNC-ALN did not modify bone tropism and lung penetration, whereas its liver and kidney accumulation was slightly higher compared with CNCs alone. In vitro studies showed that CNC-ALN did not impair ALN's effect on osteoclasts, whereas CNC-DOX confirmed the therapeutic potential against bone metastatic cancer cells. Conclusions: This study provides robust proof of the potential of CNCs as easy, flexible and specific carriers to deliver compounds to the bone.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/243137
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