Back
Full-text
Journal article

TLRs and chronic inflammation.

  • Ospelt C Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology (ZIHP), University Hospital Zurich, Gloriastr. 23, CH-8091, Zurich, Switzerland. Caroline.ospelt@usz.ch <Caroline.ospelt@usz.ch>
  • Gay S
  • 2009-10-21
Published in:
  • The international journal of biochemistry & cell biology. - 2010
Animals
Autoimmune Diseases
Chronic Disease
Humans
Immunity, Innate
Inflammation
Signal Transduction
Toll-Like Receptors
English After the discovery of Toll-like receptors (TLRs), innate immune mechanisms came back in the focus of scientific research. With more and more mechanisms of TLR biology known, it has become clear that these and also other innate immune receptors are not only of crucial importance in the immune response to invading pathogens, but also play a role in the homeostasis of commensal flora and in the response to stress and danger signals. In this respect, increasing evidence is found that inappropriate quantity or quality of TLR ligands or aberrant response to TLR activation plays a role in a variety of chronic inflammatory diseases. In this review, an overview of the currently known TLRs and their signaling pathways is given and reports about their expression and activation in chronic inflammatory diseases are recapitulated.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/243999
Statistics
Document views: 49 File downloads:
  • Full-text: 0