Journal article
Shape-switching microrobots for medical applications: the influence of shape in drug delivery and locomotion.
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Fusco S
†Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, 8092 Zurich, Switzerland.
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Huang HW
†Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, 8092 Zurich, Switzerland.
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Peyer KE
†Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, 8092 Zurich, Switzerland.
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Peters C
‡Micro and Nanosystem Group, ETH Zürich, Tannenstrasse 3, 8092 Zurich, Switzerland.
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Häberli M
†Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, 8092 Zurich, Switzerland.
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Ulbers A
†Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, 8092 Zurich, Switzerland.
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Spyrogianni A
§Particle Technology Laboratory, ETH Zürich, Sonneggstrasse 3, 8092 Zurich, Switzerland.
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Pellicer E
∥Departament de Física, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain.
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Sort J
⊥Institució Catalana de Recerca i Estudis Avançats (ICREA) and Departament de Física, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain.
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Pratsinis SE
§Particle Technology Laboratory, ETH Zürich, Sonneggstrasse 3, 8092 Zurich, Switzerland.
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Nelson BJ
†Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, 8092 Zurich, Switzerland.
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Sakar MS
†Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, 8092 Zurich, Switzerland.
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Pané S
†Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, 8092 Zurich, Switzerland.
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Published in:
- ACS applied materials & interfaces. - 2015
English
The effect of dynamic shape switching of hydrogel bilayers on the performance of self-folding microrobots is investigated for navigation in body orifices and drug release on demand. Tubular microrobots are fabricated by coupling a thermoresponsive hydrogel nanocomposite with a poly(ethylene glycol)diacrylate (PEGDA) layer, to achieve spontaneous and reversible folding from a planar rectangular structure. Graphene oxide (GO) or silica-coated superparamagnetic iron oxide nanoparticles are dispersed in the thermoresponsive hydrogel matrix to provide near-infrared (NIR) light sensitivity or magnetic actuation, respectively. The NIR light-responsive microstructures are fabricated for triggered drug delivery while magnetic nanocomposite-based microrobots are used to analyze the role of shape in locomotion. Experimental analysis and computational simulations of tubular structures show that drug release and motility can be optimized through controlled shape change. These concepts are finally applied to helical microrobots to show a possible way to achieve autonomous behavior.
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Language
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Open access status
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closed
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Identifiers
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Persistent URL
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https://sonar.ch/global/documents/244321
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