Back
Full-text
Journal article

Molecular physiology of mammalian glucokinase.

  • Iynedjian PB Department of Cell Physiolgy and Metabolism, University of Geneva School of Medicine, CMU 1 Rue Michel-Servet, 1211 Geneva 4, Switzerland. patrick.iynedjian@medecine.unige.ch
  • 2008-08-30
Published in:
  • Cellular and molecular life sciences : CMLS. - 2009
Adaptor Proteins, Signal Transducing
Brain
Congenital Hyperinsulinism
Diabetes Mellitus, Type 2
Gene Expression Regulation
Glucose
Hexokinase
Homeostasis
Humans
Insulin
Islets of Langerhans
Liver
Mitochondrial Membranes
English The glucokinase (GCK) gene was one of the first candidate genes to be identified as a human "diabetes gene". Subsequently, important advances were made in understanding the impact of GCK in the regulation of glucose metabolism. Structure elucidation by crystallography provided insight into the kinetic properties of GCK. Protein interaction partners of GCK were discovered. Gene expression studies revealed new facets of the tissue distribution of GCK, including in the brain, and its regulation by insulin in the liver. Metabolic control analysis coupled to gene overexpression and knockout experiments highlighted the unique impact of GCK as a regulator of glucose metabolism. Human GCK mutants were studied biochemically to understand disease mechanisms. Drug development programs identified small molecule activators of GCK as potential antidiabetics. These advances are summarized here, with the aim of offering an integrated view of the role of GCK in the molecular physiology and medicine of glucose homeostasis.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/245141
Statistics
Document views: 54 File downloads:
  • Full-text: 0