Efficacy of Two Cleaning Solutions for the Decontamination of 10 Antineoplastic Agents in the Biosafety Cabinets of a Hospital Pharmacy.
- Anastasi M 1.Department of Pharmacy, Geneva University Hospitals, Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland 2.School of Pharmaceutical Sciences, University of Geneva/University of Lausanne, 30, quai Ernest-Ansermet, 1211 Geneva, Switzerland.
- Rudaz S 2.School of Pharmaceutical Sciences, University of Geneva/University of Lausanne, 30, quai Ernest-Ansermet, 1211 Geneva, Switzerland.
- Queruau Lamerie T 3.Department of Pharmacy, Dunkerque Hospital, 130, avenue Louis Herbeaux, BP 6 367, 59385 Dunkerque, France.
- Odou P 3.Department of Pharmacy, Dunkerque Hospital, 130, avenue Louis Herbeaux, BP 6 367, 59385 Dunkerque, France 4.Biopharmacy, Galenic and Hospital Pharmacy Department (EA 4481, IFR114), UFR Pharmacie, Université Lille Nord de France, 1 Rue Lefèvre, 59000 Lille, France.
- Bonnabry P 1.Department of Pharmacy, Geneva University Hospitals, Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland 2.School of Pharmaceutical Sciences, University of Geneva/University of Lausanne, 30, quai Ernest-Ansermet, 1211 Geneva, Switzerland.
- Fleury-Souverain S 1.Department of Pharmacy, Geneva University Hospitals, Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland sandrine.fleury.souverain@hcuge.ch.
- 2015-05-17
Published in:
- The Annals of occupational hygiene. - 2015
antineoplastic analysis
cleaning
decontamination
detergents
hospital
occupational prevention and control
pharmacy service
2-Propanol
Antineoplastic Agents
Decontamination
Detergents
Environmental Monitoring
Equipment Contamination
Humans
Occupational Exposure
Pharmacy Service, Hospital
English
OBJECTIVE
This study aimed to evaluate two cleaning solutions for the chemical decontamination of antineoplastic agents on the surfaces of two biosafety cabinets routinely used for chemotherapy preparation in a hospital pharmacy.
METHODS
For almost 1 year (49 weeks), two different solutions were used for the weekly cleaning of two biosafety cabinets in a hospital pharmacy's centralized cytotoxic preparation unit. The solutions evaluated were a commercial solution of isopropyl alcohol (IPA) and water (70:30, vol:vol), and a detergent solution constituted by 10(-2)M of sodium dodecyl sulfate (SDS) with 20% IPA. Seven areas in each biosafety cabinet were wiped 14 times throughout the year, before and after the weekly cleaning process, according to a validated procedure. Samples were analyzed using a validated method of high-performance liquid chromatography coupled to mass spectrometry. The decontamination efficacy of these two solutions was tested for 10 antineoplastic agents: cytarabine, gemcitabine, methotrexate, etoposide phosphate, irinotecan, cyclophosphamide, ifosfamide, doxorubicin, epirubicin, and vincristine.
RESULTS
Overall decontamination efficacies observed were 82±6% and 49±11% for SDS solution and IPA, respectively. Higher contamination levels were distributed on areas frequently touched by the pharmacy technicians-such as sleeves and airlock handles-than on scale plates, gravimetric control hardware, and work benches. Detected contaminations of cyclophosphamide, ifosfamide, gemcitabine, and cytarabine were higher than those of the others agents. SDS solution was almost 20% more efficient than IPA on eight of the antineoplastic agents.
CONCLUSION
Both cleaning solutions were able to reduce contamination levels in the biosafety cabinets. The efficacy of the solution containing an anionic detergent agent (SDS) was shown to be generally higher than that of IPA and, after the SDS cleaning procedure, biosafety cabinets demonstrated acceptable contamination levels.
This study aimed to evaluate two cleaning solutions for the chemical decontamination of antineoplastic agents on the surfaces of two biosafety cabinets routinely used for chemotherapy preparation in a hospital pharmacy.
METHODS
For almost 1 year (49 weeks), two different solutions were used for the weekly cleaning of two biosafety cabinets in a hospital pharmacy's centralized cytotoxic preparation unit. The solutions evaluated were a commercial solution of isopropyl alcohol (IPA) and water (70:30, vol:vol), and a detergent solution constituted by 10(-2)M of sodium dodecyl sulfate (SDS) with 20% IPA. Seven areas in each biosafety cabinet were wiped 14 times throughout the year, before and after the weekly cleaning process, according to a validated procedure. Samples were analyzed using a validated method of high-performance liquid chromatography coupled to mass spectrometry. The decontamination efficacy of these two solutions was tested for 10 antineoplastic agents: cytarabine, gemcitabine, methotrexate, etoposide phosphate, irinotecan, cyclophosphamide, ifosfamide, doxorubicin, epirubicin, and vincristine.
RESULTS
Overall decontamination efficacies observed were 82±6% and 49±11% for SDS solution and IPA, respectively. Higher contamination levels were distributed on areas frequently touched by the pharmacy technicians-such as sleeves and airlock handles-than on scale plates, gravimetric control hardware, and work benches. Detected contaminations of cyclophosphamide, ifosfamide, gemcitabine, and cytarabine were higher than those of the others agents. SDS solution was almost 20% more efficient than IPA on eight of the antineoplastic agents.
CONCLUSION
Both cleaning solutions were able to reduce contamination levels in the biosafety cabinets. The efficacy of the solution containing an anionic detergent agent (SDS) was shown to be generally higher than that of IPA and, after the SDS cleaning procedure, biosafety cabinets demonstrated acceptable contamination levels.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1093/annhyg/mev031
- PMID 25979920
- Persistent URL
- https://sonar.ch/global/documents/245449
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