Journal article

Discovery and refinement of loci associated with lipid levels.

  • Willer CJ Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Schmidt EM Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Sengupta S Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Peloso GM Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
  • Gustafsson S Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
  • Kanoni S Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
  • Ganna A Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
  • Chen J Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Buchkovich ML Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA.
  • Mora S Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA.
  • Beckmann JS Service of Medical Genetics, Lausanne University Hospital, Lausanne, Switzerland.
  • Bragg-Gresham JL Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Chang HY Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
  • Demirkan A Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Den Hertog HM Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Do R Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
  • Donnelly LA Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom.
  • Ehret GB Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
  • Esko T Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.
  • Feitosa MF Department of Genetics, Washington University School of Medicine, USA.
  • Ferreira T Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.
  • Fischer K Estonian Genome Center of the University of Tartu, Tartu, Estonia.
  • Fontanillas P Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.
  • Fraser RM Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
  • Freitag DF Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • Gurdasani D Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
  • Heikkilä K Hjelt Institute, Department of Public Health, University of Helsinki, Finland.
  • Hyppönen E Centre For Paediatric Epidemiology and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, United Kingdom.
  • Isaacs A Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Jackson AU Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Johansson Å Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Johnson T Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Kaakinen M Biocenter Oulu, University of Oulu, Oulu, Finland.
  • Kettunen J Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland.
  • Kleber ME Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm, Germany.
  • Li X Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Luan J MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.
  • Lyytikäinen LP Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
  • Magnusson PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Mangino M Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
  • Mihailov E Estonian Genome Center of the University of Tartu, Tartu, Estonia.
  • Montasser ME Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland.
  • Müller-Nurasyid M Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
  • Nolte IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
  • O'Connell JR Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland.
  • Palmer CD Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.
  • Perola M Estonian Genome Center of the University of Tartu, Tartu, Estonia.
  • Petersen AK Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
  • Sanna S Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, 09042, Italy.
  • Saxena R Massachusetts General Hospital/Broad Institute, Harvard University, Cambridge, MA, USA.
  • Service SK Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA.
  • Shah S Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom.
  • Shungin D Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hosptial, Malmö, Sweden.
  • Sidore C Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Song C Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
  • Strawbridge RJ Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
  • Surakka I Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland.
  • Tanaka T Clinical Research Branch, National Institute Health, Baltimore, MD, USA.
  • Teslovich TM Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Thorleifsson G deCODE Genetics/Amgen, 101 Reykjavik, Iceland.
  • Van den Herik EG Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Voight BF Department of Genetics, University of Pennsylvania - School of Medicine, Philadelphia PA, 19104, USA.
  • Volcik KA Human Genetics Center, University of Texas Health Science Center - School of Public Health, Houston, TX 77030, USA.
  • Waite LL HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
  • Wong A MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom.
  • Wu Y Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA.
  • Zhang W Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
  • Absher D HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
  • Asiki G MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
  • Barroso I Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
  • Been LF Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • Bolton JL Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
  • Bonnycastle LL Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Brambilla P Department of Experimental Medicine, University of Milano Bicocca, Italy.
  • Burnett MS MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD 20782, USA.
  • Cesana G Research Centre on Public Health, University of Milano Bicocca, Italy.
  • Dimitriou M Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece.
  • Doney ASF Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom.
  • Döring A Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany.
  • Elliott P Institute of Health Sciences, University of Oulu, Finland.
  • Epstein SE MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD 20782, USA.
  • Ingi Eyjolfsson G The Laboratory in Mjodd, 108 Reykjavik, Iceland.
  • Gigante B Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Goodarzi MO Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Grallert H Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
  • Gravito ML Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • Groves CJ Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX3 7LJ, United Kingdom.
  • Hallmans G Department of Public Health and Clinical Medicine, Nutritional research, Umeå University, Umeå, Sweden.
  • Hartikainen AL Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
  • Hayward C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom.
  • Hernandez D Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
  • Hicks AA Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
  • Holm H deCODE Genetics/Amgen, 101 Reykjavik, Iceland.
  • Hung YJ Division of Endocrinology & Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
  • Illig T Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
  • Jones MR Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Kaleebu P MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
  • Kastelein JJP Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
  • Khaw KT Clinical Gerontology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Kim E Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Klopp N Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
  • Komulainen P Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  • Kumari M Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom.
  • Langenberg C MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.
  • Lehtimäki T Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
  • Lin SY Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Lindström J Diabetes Prevention Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland.
  • Loos RJF MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.
  • Mach F Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
  • McArdle WL School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom.
  • Meisinger C Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany.
  • Mitchell BD Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland.
  • Müller G Institute for Medical Informatics and Biometrics, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
  • Nagaraja R Laboratory of Genetics, National Institute on Aging, Baltimore, MD21224, USA.
  • Narisu N Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Nieminen TVM Department of Clinical Pharmacology, University of Tampere School of Medicine, Tamperew 33014, Finland.
  • Nsubuga RN MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
  • Olafsson I Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik, Iceland.
  • Ong KK MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.
  • Palotie A Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland.
  • Papamarkou T Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
  • Pomilla C Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
  • Pouta A Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
  • Rader DJ Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA.
  • Reilly MP Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA.
  • Ridker PM Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA.
  • Rivadeneira F Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Rudan I Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
  • Ruokonen A Department of Clinical Sciences/Clinical Chemistry, University of Oulu, Oulu, Finland.
  • Samani N National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
  • Scharnagl H Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
  • Seeley J MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
  • Silander K Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland.
  • Stančáková A University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
  • Stirrups K Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
  • Swift AJ Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Tiret L INSERM UMRS 937, Pierre and Marie Curie University, Paris, France.
  • Uitterlinden AG Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • van Pelt LJ Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Vedantam S Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.
  • Wainwright N Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
  • Wijmenga C LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Wild SH Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
  • Willemsen G Department of Biological Psychology, VU Univ, Amsterdam, The Netherlands.
  • Wilsgaard T Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
  • Wilson JF Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
  • Young EH Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
  • Zhao JH MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.
  • Adair LS Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA.
  • Arveiler D Department of Epidemiology and Public Health, EA 3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France.
  • Assimes TL Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Bandinelli S Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
  • Bennett F Chemical Pathology, Department of Pathology, University of the West Indies, Mona, Kingston 7, Jamaica.
  • Bochud M Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland.
  • Boehm BO Division of Endocrinology and Diabetes, Department of Internal Medicine, Ulm University Medical Centre, Ulm, Germany.
  • Boomsma DI Department of Biological Psychology, VU Univ, Amsterdam, The Netherlands.
  • Borecki IB Department of Genetics, Washington University School of Medicine, USA.
  • Bornstein SR Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
  • Bovet P Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland.
  • Burnier M Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland.
  • Campbell H Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
  • Chakravarti A Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Chambers JC Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
  • Chen YI Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Collins FS Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Cooper RS Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA.
  • Danesh J Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • Dedoussis G Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece.
  • de Faire U Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Feranil AB Office of Population Studies Foundation, University of San Carlos, Talamban, Cebu City, Philippines.
  • Ferrières J Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France.
  • Ferrucci L Clinical Research Branch, National Institute Health, Baltimore, MD, USA.
  • Freimer NB Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA.
  • Gieger C Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
  • Groop LC Department of Clinical Sciences, Lund University, SE-20502, Malmö, Sweden.
  • Gudnason V Icelandic Heart Association, Kopavogur, Iceland.
  • Gyllensten U Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Hamsten A Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
  • Harris TB Laboratory of Epidemiology, Demography, and Biometry, National Institute on Ageing, Bethesda, MD, USA.
  • Hingorani A Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom.
  • Hirschhorn JN Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.
  • Hofman A Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Hovingh GK Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
  • Hsiung CA Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
  • Humphries SE Cardiovascular Genetics, BHF Laboratories, Institute Cardiovascular Science, University College London, London, United Kingdom.
  • Hunt SC Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Hveem K HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
  • Iribarren C Kaiser Permanente, Division of Research, Oakland, CA, USA.
  • Järvelin MR Biocenter Oulu, University of Oulu, Oulu, Finland.
  • Jula A Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland.
  • Kähönen M Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33014, Finland.
  • Kaprio J Hjelt Institute, Department of Public Health, University of Helsinki, Finland.
  • Kesäniemi A Institute of Clinical Medicine, Department of Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland.
  • Kivimaki M Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom.
  • Kooner JS Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom.
  • Koudstaal PJ Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Krauss RM Children's Hospital Oakland Research Institute, 5700 Martin Luther King Junior Way, Oakland, CA 94609, USA.
  • Kuh D MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom.
  • Kuusisto J Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
  • Kyvik KO Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark.
  • Laakso M Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
  • Lakka TA Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  • Lind L Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Lindgren CM Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.
  • Martin NG Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Queensland 4029, Australia.
  • März W Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Ludolf-Krehl-Strasse 7-11, 68167 Mannheim, Germany.
  • McCarthy MI Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.
  • McKenzie CA Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica.
  • Meneton P U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006 Paris, France.
  • Metspalu A Estonian Genome Center of the University of Tartu, Tartu, Estonia.
  • Moilanen L Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
  • Morris AD Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom.
  • Munroe PB Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Njølstad I Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
  • Pedersen NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Power C Centre For Paediatric Epidemiology and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, United Kingdom.
  • Pramstaller PP Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
  • Price JF Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
  • Psaty BM Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
  • Quertermous T Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Rauramaa R Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  • Saleheen D Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • Salomaa V Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland.
  • Sanghera DK Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • Saramies J South Karelia Central Hospital, Lappeenranta, Finland.
  • Schwarz PEH Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
  • Sheu WH Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Shuldiner AR Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland.
  • Siegbahn A Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
  • Spector TD Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
  • Stefansson K deCODE Genetics/Amgen, 101 Reykjavik, Iceland.
  • Strachan DP Division of Population Health Sciences and Education, St George's, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.
  • Tayo BO Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA.
  • Tremoli E Department of Pharmacological Sciences, University of Milan, Monzino Cardiology Center, IRCCS, Milan, Italy.
  • Tuomilehto J Diabetes Prevention Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland.
  • Uusitupa M Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.
  • van Duijn CM Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Vollenweider P Department of Medicine, Lausanne University Hospital, Switzerland.
  • Wallentin L Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
  • Wareham NJ MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.
  • Whitfield JB Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Queensland 4029, Australia.
  • Wolffenbuttel BHR LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands.
  • Ordovas JM Department of Cardiovascular Epidemiology and Population Genetics, National Center for rdiovascular Investigation, Madrid, Spain.
  • Boerwinkle E Human Genetics Center, University of Texas Health Science Center - School of Public Health, Houston, TX 77030, USA.
  • Palmer CNA Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom.
  • Thorsteinsdottir U deCODE Genetics/Amgen, 101 Reykjavik, Iceland.
  • Chasman DI Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA.
  • Rotter JI Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Franks PW Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hosptial, Malmö, Sweden.
  • Ripatti S Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
  • Cupples LA Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
  • Sandhu MS Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
  • Rich SS Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
  • Boehnke M Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Deloukas P Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
  • Kathiresan S Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
  • Mohlke KL Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA.
  • Ingelsson E Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
  • Abecasis GR Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
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  • 2013-10-08
Published in:
  • Nature genetics. - 2013
English Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
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  • English
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https://sonar.ch/global/documents/245452
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