Journal article
Tolerance of staphylococci to bactericidal antibiotics.
- 2006-05-03
Published in:
- Injury. - 2006
Animals
Anti-Bacterial Agents
Disease Models, Animal
Drug Resistance, Bacterial
Guinea Pigs
Humans
Orthopedic Procedures
Prostheses and Implants
Prosthesis-Related Infections
Rats
Staphylococcal Infections
Staphylococcus
Virulence
English
Antibiotic therapy for deep-seated staphylococcal infections, especially when they are associated with artificial devices used for orthopedic surgery is often associated with failure. Standard anti-staphylococcal bactericidal antibiotics, such as semi-synthetic penicillins, cephalosporins, or glycopeptides, are effective when given prophylactically in clinical conditions or experimental trials of implant-related infections. However, the efficacy of all anti-staphylococcal agents is seriously diminished on already established implant-related deep-seated infections, which then frequently require surgical implant removal to obtain a cure. The failure of antibiotic therapy to cure established staphylococcal foreign-body infections may arise in part from a broad-spectrum phenotypic tolerance expressed in vivo to different classes of antimicrobial agents. The molecular and physiological mechanisms of this in vivo tolerance remain poorly understood.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.injury.2006.04.004
- PMID 16651066
- Persistent URL
- https://sonar.ch/global/documents/245454
Statistics
Document views: 22
File downloads: