The Italian Alzheimer's Disease Neuroimaging Initiative (I-ADNI): validation of structural MR imaging.
- Cavedo E LENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS Centro San Giovanni di Dio-FBF, Brescia, Italy Cognition, Neuroimaging and Brain Diseases Laboratory, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière (CRICM-UMRS 975), Université Pierre et Marie Curie-Paris, France.
- Redolfi A LENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS Centro San Giovanni di Dio-FBF, Brescia, Italy.
- Angeloni F IRCCS Fondazione SDN per la Ricerca e l'Alta Formazione in Diagnostica Nucleare, Naples, Italy.
- Babiloni C Laboratory of High resolution EEG, Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy IRCCS San Raffaele Pisana, Rome, Italy.
- Lizio R IRCCS San Raffaele Pisana, Rome, Italy.
- Chiapparini L Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta," Milan, Italy.
- Bruzzone MG Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta," Milan, Italy.
- Aquino D Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta," Milan, Italy.
- Sabatini U Santa Lucia Foundation, Radiology Department, Rome, Italy.
- Alesiani M Santa Lucia Foundation, Radiology Department, Rome, Italy.
- Cherubini A Santa Lucia Foundation, Radiology Department, Rome, Italy.
- Salvatore E Department of Neurosciences, Reproductive Sciences and Odontostomatology, University Of Naples Federico II, Naples, Italy.
- Soricelli A IRCCS Fondazione SDN per la Ricerca e l'Alta Formazione in Diagnostica Nucleare, Naples, Italy Department of Studies of Institutions and Territorial Systems, University of Naples Parthenope, Naples, Italy.
- Vernieri F Neurol. University "Campus Biomedico" Rome, Italy.
- Scrascia F Neurol. University "Campus Biomedico" Rome, Italy.
- Sinforiani E IRCCS C. Mondino National Institute of Neurology Foundation and University of Pavia, Pavia, Italy.
- Chiarati P IRCCS C. Mondino National Institute of Neurology Foundation and University of Pavia, Pavia, Italy.
- Bastianello S IRCCS C. Mondino National Institute of Neurology Foundation and University of Pavia, Pavia, Italy.
- Montella P Department of Neurological Sciences, Second University of Naples, Naples, Italy.
- Corbo D Department of Neurological Sciences, Second University of Naples, Naples, Italy.
- Tedeschi G Department of Neurological Sciences, Second University of Naples, Naples, Italy.
- Marino S IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
- Baglieri A IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
- De Salvo S IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
- Carducci F Laboratory of Neuroimaging, Department of Physiology and Pharmacology, University of Rome "La Sapienza", Rome, Italy.
- Quattrocchi CC IRCCS "Ospedale Pediatrico Bambino Gesù", Roma, Italy.
- Cobelli M Neuroradiology Unit, Fondazione Poliambulanza, Brescia, Italy.
- Frisoni GB LENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS Centro San Giovanni di Dio-FBF, Brescia, Italy Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.
- 2014-03-01
Published in:
- Journal of Alzheimer's disease : JAD. - 2014
Alzheimer's disease
hippocampus
intracranial volume
magnetic resonance imaging
mild cognitive impairment
standardized operating procedures
Alzheimer Disease
Analysis of Variance
Brain
Female
Humans
Image Processing, Computer-Assisted
Italy
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Reproducibility of Results
English
BACKGROUND
The North American Alzheimer's Disease Neuroimaging Initiative (NA-ADNI) was the first program to develop standardized procedures for Alzheimer's disease (AD) imaging biomarker collection.
OBJECTIVE
We describe the validation of acquisition and processing of structural magnetic resonance imaging (MRI) in different Italian academic AD clinics following NA-ADNI procedures.
METHODS
373 patients with subjective memory impairment (n = 12), mild cognitive impairment (n = 92), Alzheimer's dementia (n = 253), and frontotemporal dementia (n = 16) were enrolled in 9 Italian centers. 22 cognitively healthy elderly controls were also included. MRI site qualification and MP-RAGE quality assessment was applied following the NA-ADNI procedures. Indices of validity were: (i) NA-ADNI phantom's signal-to-noise and contrast-to-noise ratio, (ii) proportion of images passing quality control, (iii) comparability of automated intracranial volume (ICV) estimates across scanners, and (iv) known-group validity of manual hippocampal volumetry.
RESULTS
Results on Phantom and Volunteers scans showed that I-ADNI acquisition parameters were comparable with those one of the ranked-A ADNI scans. Eighty-seven percent of I-ADNI MPRAGE images were ranked of high quality in comparison of 69% of NA-ADNI. ICV showed homogeneous variances across scanners except for Siemens scanners at 3.0 Tesla (p = 0.039). A significant difference in hippocampal volume was found between AD and controls on 1.5 Tesla scans (p < 0.001), confirming known group validity test.
CONCLUSION
This study has provided standardization of MRI acquisition and imaging marker collection across different Italian clinical units and equipment. This is a mandatory step to the implementation of imaging biomarkers in clinical routine for early and differential diagnosis.
The North American Alzheimer's Disease Neuroimaging Initiative (NA-ADNI) was the first program to develop standardized procedures for Alzheimer's disease (AD) imaging biomarker collection.
OBJECTIVE
We describe the validation of acquisition and processing of structural magnetic resonance imaging (MRI) in different Italian academic AD clinics following NA-ADNI procedures.
METHODS
373 patients with subjective memory impairment (n = 12), mild cognitive impairment (n = 92), Alzheimer's dementia (n = 253), and frontotemporal dementia (n = 16) were enrolled in 9 Italian centers. 22 cognitively healthy elderly controls were also included. MRI site qualification and MP-RAGE quality assessment was applied following the NA-ADNI procedures. Indices of validity were: (i) NA-ADNI phantom's signal-to-noise and contrast-to-noise ratio, (ii) proportion of images passing quality control, (iii) comparability of automated intracranial volume (ICV) estimates across scanners, and (iv) known-group validity of manual hippocampal volumetry.
RESULTS
Results on Phantom and Volunteers scans showed that I-ADNI acquisition parameters were comparable with those one of the ranked-A ADNI scans. Eighty-seven percent of I-ADNI MPRAGE images were ranked of high quality in comparison of 69% of NA-ADNI. ICV showed homogeneous variances across scanners except for Siemens scanners at 3.0 Tesla (p = 0.039). A significant difference in hippocampal volume was found between AD and controls on 1.5 Tesla scans (p < 0.001), confirming known group validity test.
CONCLUSION
This study has provided standardization of MRI acquisition and imaging marker collection across different Italian clinical units and equipment. This is a mandatory step to the implementation of imaging biomarkers in clinical routine for early and differential diagnosis.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.3233/JAD-132666
- PMID 24577455
- Persistent URL
- https://sonar.ch/global/documents/245607
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