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Mismatches in the Influenza A Virus RNA Panhandle Prevent Retinoic Acid-Inducible Gene I (RIG-I) Sensing by Impairing RNA/RIG-I Complex Formation.

  • Anchisi S Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Guerra J Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Mottet-Osman G Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Garcin D Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland Dominique.Garcin@unige.ch.
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  • 2015-10-09
Published in:
  • Journal of virology. - 2016
Base Pair Mismatch
Cell Line
DEAD Box Protein 58
DEAD-box RNA Helicases
Epithelial Cells
Host-Pathogen Interactions
Humans
Immune Evasion
Immunity, Innate
Influenza A virus
Nucleic Acid Conformation
Protein Binding
RNA, Double-Stranded
RNA, Viral
RNA-Binding Proteins
English Influenza virus RNA (vRNA) promoter panhandle structures are believed to be sensed by retinoic acid-inducible gene I (RIG-I). The occurrence of mismatches in this double-stranded RNA structure raises questions about their effect on innate sensing. Our results suggest that mismatches in vRNA promoters decrease binding to RIG-I in vivo, affecting RNA/RIG-I complex formation and preventing RIG-I activation. These results can be inferred to apply to other viruses and suggest that mismatches may represent a general viral strategy to escape RIG-I sensing.
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  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/246240
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