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Discovery and functional characterization of cardiovascular long noncoding RNAs.
Journal article

Discovery and functional characterization of cardiovascular long noncoding RNAs.

  • Ounzain S Experimental Cardiology Unit, Department of Medicine, University of Lausanne Medical School, Lausanne, Switzerland. Electronic address: samir.ounzain@chuv.ch.
  • Burdet F Vital-IT, Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland.
  • Ibberson M Vital-IT, Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland.
  • Pedrazzini T Experimental Cardiology Unit, Department of Medicine, University of Lausanne Medical School, Lausanne, Switzerland. Electronic address: thierry.pedrazzini@chuv.ch.
  • 2015-09-27
Published in:
  • Journal of molecular and cellular cardiology. - 2015
Cardiovascular disease
Discovery
Functional characterization
Genomics
Long noncoding RNA
Animals
Cardiovascular System
Humans
Molecular Sequence Annotation
RNA, Long Noncoding
English Recent advances in sequencing and genomic technologies have resulted in the discovery of thousands of previously unannotated long noncoding RNAs (lncRNAs). However, their function in the cardiovascular system remains elusive. Here we review and discuss considerations for cardiovascular lncRNA discovery, annotation and functional characterization. Although we primarily focus on the heart, the proposed pipeline should foster functional and mechanistic exploration of these transcripts in various cardiovascular pathologies. Moreover, these insights could ultimately lead to novel therapeutic approaches targeting lncRNAs for the amelioration of cardiovascular diseases including heart failure.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/246245
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