Pyroptosis: Caspase-11 Unlocks the Gates of Death.
- de Gassart A Department of Biochemistry, University of Lausanne, 155 Ch. Des Boveresses, Epalinges 1066, Switzerland.
- Martinon F Department of Biochemistry, University of Lausanne, 155 Ch. Des Boveresses, Epalinges 1066, Switzerland. Electronic address: fabio.martinon@unil.ch.
- 2015-11-21
Published in:
- Immunity. - 2015
Pyroptosis
caspase-11
danger signals
inflammation
Animals
Caspases
Connexins
Humans
Nerve Tissue Proteins
Pyroptosis
Receptors, Purinergic P2X7
Shock, Septic
English
How inflammatory caspases trigger pyroptotic cell death is mostly unexplained. In this issue of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-dependent pyroptosis.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/j.immuni.2015.10.024
- PMID 26588774
- Persistent URL
- https://sonar.ch/global/documents/246271
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