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RXRs: collegial partners.
Journal article

RXRs: collegial partners.

  • Gilardi F Center for Integrative Genomics, University of Lausanne, Genopode Building, 1015, Lausanne, Switzerland, Federica.Gilardi@unil.ch.
  • Desvergne B
  • 2014-06-26
Published in:
  • Sub-cellular biochemistry. - 2014
Alitretinoin
Animals
Gene Expression Regulation
Humans
Ligands
Mice
Protein Binding
Protein Isoforms
Protein Multimerization
Protein Structure, Tertiary
Receptors, Retinoic Acid
Response Elements
Retinoid X Receptors
Signal Transduction
Tretinoin
English Retinoid X Receptors (RXR) were initially identified as nuclear receptors binding with stereo-selectivity the vitamin A derivative 9-cis retinoic acid, although the relevance of this molecule as endogenous activator of RXRs is still elusive. Importantly, within the nuclear receptor superfamily, RXRs occupy a peculiar place, as they are obligatory partners for a number of other nuclear receptors, thus integrating the corresponding signaling pathways. In this chapter, we describe the structural features allowing RXR to form homo- and heterodimers, and the functional consequences of this unique ability. Furthermore, we discuss the importance of studying RXR activity at a genome-wide level in order to comprehensively address the biological implications of their action that is fundamental to understand to what extent RXRs could be exploited as new therapeutic targets.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/246288
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