Journal article

Genomic insights into the Ixodes scapularis tick vector of Lyme disease.

  • Gulia-Nuss M Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
  • Nuss AB Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
  • Meyer JM Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
  • Sonenshine DE Department of Biological Sciences, Old Dominion University, Norfolk, Virginina 23529, USA.
  • Roe RM Department of Entomology, North Carolina State University, Raleigh, North Carolina 27695, USA.
  • Waterhouse RM Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland.
  • Sattelle DB Centre for Respiratory Biology, UCL Respiratory Department, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK.
  • de la Fuente J SaBio, Instituto de Investigación en Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, Ronda de Toledo sn, Ciudad Real 13005, Spain.
  • Ribeiro JM Laboratory of Malaria and Vector Research, NIAID, Rockville, Maryland 20852, USA.
  • Megy K VectorBase/EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.
  • Thimmapuram J Bioinformatics Core, Purdue University, West Lafayette, Indiana 47907, USA.
  • Miller JR J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Walenz BP J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Koren S J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Hostetler JB J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Thiagarajan M J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Joardar VS J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Hannick LI J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Bidwell S J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Hammond MP VectorBase/EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.
  • Young S Genome Sequencing and Analysis Program, Broad Institute, Cambridge, Massachusetts 02142, USA.
  • Zeng Q Genome Sequencing and Analysis Program, Broad Institute, Cambridge, Massachusetts 02142, USA.
  • Abrudan JL Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.
  • Almeida FC Departament de Genètica &Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona E-08028, Spain.
  • Ayllón N SaBio, Instituto de Investigación en Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, Ronda de Toledo sn, Ciudad Real 13005, Spain.
  • Bhide K Bioinformatics Core, Purdue University, West Lafayette, Indiana 47907, USA.
  • Bissinger BW Department of Entomology, North Carolina State University, Raleigh, North Carolina 27695, USA.
  • Bonzon-Kulichenko E Vascular Physiopathology, Centro Nacional de Investigaciones Cardiovasculares, Madrid 28029, Spain.
  • Buckingham SD Centre for Respiratory Biology, UCL Respiratory Department, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK.
  • Caffrey DR Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
  • Caimano MJ Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.
  • Croset V Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
  • Driscoll T Genetics, Bioinformatics, and Computational Biology Program, Virginia Bioinformatics Institute at Virginia Tech, Blacksburg, Virginia 24061, USA.
  • Gilbert D Department of Biology, Indiana University, Bloomington, Indiana 47405, USA.
  • Gillespie JJ Genetics, Bioinformatics, and Computational Biology Program, Virginia Bioinformatics Institute at Virginia Tech, Blacksburg, Virginia 24061, USA.
  • Giraldo-Calderón GI Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
  • Grabowski JM Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
  • Jiang D Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA.
  • Khalil SMS Department of Microbial Molecular Biology, Agricultural Genetic Engineering Research Institute, Giza 12619, Egypt.
  • Kim D Department of Entomology, Texas A&M University, College Station, Texas 77843, USA.
  • Kocan KM Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, 250 McElroy Hall, Stillwater, Oklahama 74078, USA.
  • Koči J Department of Entomology, Kansas State University, Manhattan, Kansas 66506, USA.
  • Kuhn RJ Department Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, Indiana 47907, USA.
  • Kurtti TJ Department of Entomology, University of Minnesota, St Paul, Minnesota 55108, USA.
  • Lees K Department of Neurosystems, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
  • Lang EG Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
  • Kennedy RC Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94143, USA.
  • Kwon H Department of Entomology, Texas A&M University, College Station, Texas 77843, USA.
  • Perera R Department Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, Indiana 47907, USA.
  • Qi Y Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA.
  • Radolf JD Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.
  • Sakamoto JM Department of Entomology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
  • Sánchez-Gracia A Departament de Genètica &Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona E-08028, Spain.
  • Severo MS Department of Entomology, Center for Disease Vector Research, University of California, Riverside, California 92506, USA.
  • Silverman N Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
  • Šimo L Department of Entomology, Kansas State University, Manhattan, Kansas 66506, USA.
  • Tojo M Department of Pathology, Cambridge Genomic Services, University of Cambridge, Cambridge CB2 1QP, UK.
  • Tornador C Department of Experimental and Health Sciences, Universidad Pompeu Fabra, Barcelona 08003, Spain.
  • Van Zee JP Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
  • Vázquez J Vascular Physiopathology, Centro Nacional de Investigaciones Cardiovasculares, Madrid 28029, Spain.
  • Vieira FG Departament de Genètica &Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona E-08028, Spain.
  • Villar M SaBio, Instituto de Investigación en Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, Ronda de Toledo sn, Ciudad Real 13005, Spain.
  • Wespiser AR Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
  • Yang Y Department of Entomology, Texas A&M University, College Station, Texas 77843, USA.
  • Zhu J Department of Entomology, North Carolina State University, Raleigh, North Carolina 27695, USA.
  • Arensburger P Department of Biological Sciences, California State Polytechnic University, Pomona, California 91768, USA.
  • Pietrantonio PV Department of Entomology, Texas A&M University, College Station, Texas 77843, USA.
  • Barker SC Parasitology Section, School of Chemistry &Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.
  • Shao R GeneCology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, Queensland 4556, Australia.
  • Zdobnov EM Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland.
  • Hauser F Department of Biology, Center for Functional and Comparative Insect Genomics, University of Copenhagen, Copenhagen DK-2100, Denmark.
  • Grimmelikhuijzen CJP Department of Biology, Center for Functional and Comparative Insect Genomics, University of Copenhagen, Copenhagen DK-2100, Denmark.
  • Park Y Department of Entomology, Kansas State University, Manhattan, Kansas 66506, USA.
  • Rozas J Departament de Genètica &Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona E-08028, Spain.
  • Benton R Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne CH-1015, Switzerland.
  • Pedra JHF Department of Entomology, Center for Disease Vector Research, University of California, Riverside, California 92506, USA.
  • Nelson DR Department of Microbiology, Immunology &Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
  • Unger MF Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.
  • Tubio JMC Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
  • Tu Z Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA.
  • Robertson HM Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
  • Shumway M J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Sutton G J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Wortman JR J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Lawson D VectorBase/EMBL-EBI, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.
  • Wikel SK Department of Medical Sciences, Frank H. Netter MD School of Medicine at Quinnipiac University, Hamden, Connecticut 06518, USA.
  • Nene VM J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Fraser CM Institute for Genome Sciences, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
  • Collins FH Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.
  • Birren B The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Nelson KE J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Caler E J. Craig Venter Institute, Rockville, Maryland 20850, USA.
  • Hill CA Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USA.
Show more…
  • 2016-02-10
Published in:
  • Nature communications. - 2016
English Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/246381
Statistics

Document views: 54 File downloads:
  • Full-text: 0