Microbiota Control of Malaria Transmission.

Soares MP; Yilmaz B

doi:10.1016/j.pt.2015.11.004

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Journal article

Microbiota Control of Malaria Transmission.

Soares MP Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, 2780-156, Oeiras, Portugal. Electronic address: mpsoares@igc.gulbenkian.pt.
Yilmaz B Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, 2780-156, Oeiras, Portugal; Current address: Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland. Electronic address: bahtiyar_yilmaz@outlook.com.

2016-01-18

Published in:

Trends in parasitology. - 2016

English Stable mutualistic interactions between multicellular organisms and microbes are an evolutionarily conserved process with a major impact on host physiology and fitness. Humans establish such interactions with a consortium of microorganisms known as the microbiota. Despite the mutualistic nature of these interactions, some bacterial components of the human microbiota express immunogenic glycans that elicit glycan-specific antibody (Ab) responses. The ensuing circulating Abs are protective against infections by pathogens that express those glycans, as demonstrated for Plasmodium, the causative agent of malaria. Presumably, a similar protective Ab response acts against other vector-borne diseases.

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