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Wernicke-Kleist-Leonhard phenotypes 
of endogenous psychoses: a review of their validity
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  • Foucher JR ICube - CNRS UMR 7357, neurophysiology, FMTS, University of Strasbourg, France ; CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, France.
  • Gawlik M Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany.
  • Roth JN Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany.
  • de Crespin de Billy C ICube - CNRS UMR 7357, neurophysiology, FMTS, University of Strasbourg, France; CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, France.
  • Jeanjean LC IICube - CNRS UMR 7357, neurophysiology, FMTS, University of Strasbourg, France; CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, France.
  • Obrecht A ICube - CNRS UMR 7357, neurophysiology, FMTS, University of Strasbourg, France; Pôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, France.
  • Mainberger O ICube - CNRS UMR 7357, neurophysiology, FMTS, University of Strasbourg, France. CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, France.
  • Clauss JME Pôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, France. SAGE - CNRS UMR 7363, FMTS, University of Strasbourg, France.
  • Elowe J Department of Psychiatry, Prangins Psychiatric Hospital (CHUV), Route de Benex, Prangins, Switzerland.
  • Weibel S IPôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, France; Physiopathologie et Psychopathologie Cognitive de la Schizophrénie - INSERM 1114, FMTS, University of Strasbourg, France.
  • Schorr B Pôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, France; Physiopathologie et Psychopathologie Cognitive de la Schizophrénie - INSERM 1114, FMTS, University of Strasbourg, France.
  • Cetkovich M Institute of Translational and Cognitive Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
  • Morra C ICube - CNRS UMR 7357, neurophysiology, FMTS, University of StInstitute of Translational and Cognitive Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Sanatorio Morra, Córdoba, Argentina.
  • Rebok F "Servicio de Emergencia", Acute Inpatient Unit, Moyano Neuropsychiatric Hospital, Buenos Aires, Argentina.
  • Ban TA International Network for the History of Neuropsychopharmacology (INHN), Córdoba, Argentina.
  • Bollmann B Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Berlin, Germany.
  • Roser MM Department of Psychiatry, Mondor Hospital France, Creteil, France.
  • Hanke MS Universitäre psychiatrische Dienste Bern, Spiez, Switzerland.
  • Jabs BE Klinik für Psychiatrie and Psychotherapie, Städtisches Klinikum Dresden, Dresden, Germany.
  • Franzek EJ Yes We Can Clinics, Department of Research and Development, Eindhoven, The Netherlands.
  • Berna F Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany; Department of Psychiatry, Prangins Psychiatric Hospital (CHUV), Route de Benex, Prangins, Switzerland.
  • Pfuhlmann B IKlinik für Psychiatrie and Psychotherapie, Städtisches Klinikum Dresden, Dresden, Germany.
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  • 2020-07-24
Published in:
  • Dialogues in clinical neuroscience. - 2020
endogenous psychosis
Kleist
Leonhard
Wernicke
affect laden paraphrenia
bipolar
cataphasia
catatonia
classification
cycloid psychoses
deep phenotyping
epistemology
hebephrenia
periodic catatonia
phenotype
schizophrenia
supersensitivity psychosis
system schizophrenia
unipolar
English While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-Leonhard (WKL) pathway has optimized the descriptions of 35 major phenotypes using common medical heuristics on lifelong diachronic observations. Regarding their construct validity, WKL phenotypes have good reliability and predictive and face validity. WKL phenotypes come with remarkable evidence for differential validity on age of onset, familiality, pregnancy complications, precipitating factors, and treatment response. Most impressive is the replicated separation of high- and low-familiality phenotypes. Created in the purest tradition of the biomedical paradigm, the WKL phenotypes deserve to be contrasted as credible alternatives with other approaches currently under discussion.
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Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/24834
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