Anything but Ordinary - Emerging Splicing Mechanisms in Eukaryotic Gene Regulation.
- Gehring NH Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany. Electronic address: ngehring@uni-koeln.de.
- Roignant JY Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany. Electronic address: jean-yves.roignant@unil.ch.
- 2020-11-18
Published in:
- Trends in genetics : TIG. - 2020
RNA modifications
RNA-binding protein
circular RNA
cotranscriptional splicing
pre-mRNA splicing
recursive splicing
English
Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene expression. The identification of the actual splice sites and the proper removal of introns are essential for the production of the desired mRNA isoforms and their encoded proteins. While the basic mechanisms of splicing regulation are well understood, recent work has uncovered a growing number of noncanonical splicing mechanisms that play key roles in the regulation of gene expression. In this review, we summarize the current principles of splicing regulation, including the impact of cis and trans regulatory elements, as well as the influence of chromatin structure, transcription, and RNA modifications. We further discuss the recent development of emerging splicing mechanisms, such as recursive and back splicing, and their impact on gene expression.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1016/j.tig.2020.10.008
- PMID 33203572
- Persistent URL
- https://sonar.ch/global/documents/24894
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