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Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells.
Journal article

Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells.

  • 1998-10-24
Published in:
  • Biochemical and biophysical research communications. - 1998
Antioxidants
Carcinoma
Carotenoids
Cell Division
Drug Synergism
Humans
Lycopene
Male
Prostatic Neoplasms
Tumor Cells, Cultured
Vitamin E
English The effect of lycopene alone or in association with other antioxidants was studied on the growth of two different human prostate carcinoma cell lines (the androgen insensitive DU-145 and PC-3). It was found that lycopene alone was not a potent inhibitor of prostate carcinoma cell proliferation. However, the simultaneous addition of lycopene together with alpha-tocopherol, at physiological concentrations (less than 1 microM and 50 microM, respectively), resulted in a strong inhibitory effect of prostate carcinoma cell proliferation, which reached values close to 90 %. The effect of lycopene with alpha-tocopherol was synergistic and was not shared by beta-tocopherol, ascorbic acid and probucol.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/249419
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