A brief history of TOR
- Loewith, Robbie Department of Molecular Biology, National Centres of Competence in Research ‘Frontiers in Genetics’ and ‘Chemical Biology’, University of Geneva, Sciences III, 30 quai Ernest Ansermet, CH-1211 Geneva, Switzerland
- 2011-3-22
Published in:
- Biochemical Society Transactions. - Portland Press Ltd.. - 2011, vol. 39, no. 2, p. 437-442
English
The TOR (target of rapamycin) serine/threonine kinases are fascinating in that they influence many different aspects of eukaryote physiology including processes often dysregulated in disease. Beginning with the initial characterization of rapamycin as an antifungal agent, studies with yeast have contributed greatly to our understanding of the molecular pathways in which TORs operate. Recently, building on advances in quantitative MS, the rapamycin-dependent phosphoproteome in the budding yeast Saccharomyces cerevisiae was elucidated. These studies emphasize the central importance of TOR and highlight its many previously unrecognized functions. One of these, the regulation of intermediary metabolism, is discussed.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1042/bst0390437
- ISSN 0300-5127
- Persistent URL
- https://sonar.ch/global/documents/249970
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