Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge.
- Stone V Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, Scotland, UK
- Miller MR Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK
- Clift MJD Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland
- Elder A University of Rochester Medical Center, Rochester, New York
- Mills NL Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK
- Møller P Department of Public Health, University of Copenhagen, Copenhagen, Denmark
- Schins RPF IUF Leibniz-Institut für Umweltmedizinische Forschung, Düsseldorf, Germany
- Vogel U National Research Centre for the Working Environment, Copenhagen, Denmark
- Kreyling WG Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Munich, Germany
- Alstrup Jensen K National Research Centre for the Working Environment, Copenhagen, Denmark
- Kuhlbusch TAJ Air Quality & Sustainable Nanotechnology Unit, Institut für Energie- und Umwelttechnik e. V. (IUTA), Duisburg, Germany
- Schwarze PE Norwegian Institute of Public Health, Oslo, Norway
- Hoet P Center for Environment and Health, Katholieke Universiteit Leuven, Leuven, Belgium
- Pietroiusti A Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
- De Vizcaya-Ruiz A Departmento de Toxicología, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, México
- Baeza-Squiban A Paris Diderot University, Paris, France
- Teixeira JP National Institute of Health, Porto, Portugal
- Tran CL Institute of Occupational Medicine, Edinburgh, Scotland, UK
- Cassee FR National Institute for Public Health and the Environment, Bilthoven, Netherlands
- 2017-10-12
Published in:
- Environmental health perspectives. - 2017
English
BACKGROUND
A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models.
OBJECTIVES
NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP.
METHODS
A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas.
DISCUSSION
Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously.
CONCLUSION
There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa. https://doi.org/10.1289/EHP424.
A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models.
OBJECTIVES
NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP.
METHODS
A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas.
DISCUSSION
Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas in which additional research prioritization would facilitate both research fields simultaneously.
CONCLUSION
There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa. https://doi.org/10.1289/EHP424.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1289/EHP424
- PMID 29017987
- Persistent URL
- https://sonar.ch/global/documents/250653
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