Metabolic chiral inversion of ibuprofen in isolated rat hepatocytes.
Journal article

Metabolic chiral inversion of ibuprofen in isolated rat hepatocytes.

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  • 1990-01-01
Published in:
  • Chirality. - 1990
English Ibuprofen was used to demonstrate that isolated rat hepatocytes offer a suitable in vitro model to investigate the metabolic chiral inversion of anti-inflammatory 2-arylpropionic acids (profens). The inversion of the pharmacologically inactive (-)-(R)-ibuprofen to the active (+)-(S)-ibuprofen was shown to obey apparent first-order kinetics during 5 h and to increase linearly with increasing hepatocyte concentration up to 4 x 10(5) cells/ml. No elimination of (R)-ibuprofen by routes other than inversion was seen, whereas the elimination of (S)-ibuprofen appeared to be saturable.
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  • English
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closed
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https://sonar.ch/global/documents/250833
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