Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey.
- Datema MR Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
- Zuidmeer-Jongejan L Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
- Asero R Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.
- Barreales L Clinical Epidemiology Unit, Preventive Medicine Department, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.
- Belohlavkova S Pediatric Department, Faculty Hospital Bulovka, Prague, Czech Republic.
- de Blay F Allergy Division, Chest Disease Department, University Hospital of Strasbourg, Strasbourg, France.
- Bures P Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.
- Clausen M Faculty of Medicine, University of Iceland, Landspitali University Hospital, Reykjavik, Iceland.
- Dubakiene R Medical Faculty, Vilnius University, Vilnius, Lithuania.
- Gislason D Faculty of Medicine, University of Iceland, Landspitali University Hospital, Reykjavik, Iceland.
- Jedrzejczak-Czechowicz M Department of Immunology, Rheumatology and Allergy, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
- Kowalski ML Department of Immunology, Rheumatology and Allergy, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
- Knulst AC Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
- Kralimarkova T Clinic of Allergy and Asthma, Medical University of Sofia, Sofia, Bulgaria.
- Le TM Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
- Lovegrove A Department of Plant Biology and Crop Science, Rothamsted Research, Harpenden, United Kingdom.
- Marsh J Institute of Inflammation and Repair, Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom.
- Papadopoulos NG Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece; Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, United Kingdom.
- Popov T Division of Allergology, Paul-Ehrlich-Insitut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.
- Del Prado N Clinical Epidemiology Unit, Preventive Medicine Department, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.
- Purohit A Allergy Division, Chest Disease Department, University Hospital of Strasbourg, Strasbourg, France.
- Reese G Division of Allergology, Paul-Ehrlich-Insitut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.
- Reig I Allergy Department, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.
- Seneviratne SL Department of Clinical Immunology, St Mary's Hospital, and Imperial College London, London, United Kingdom.
- Sinaniotis A Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
- Versteeg SA Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
- Vieths S Division of Allergology, Paul-Ehrlich-Insitut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.
- Zwinderman AH Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, Amsterdam, The Netherlands.
- Mills C Institute of Inflammation and Repair, Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom.
- Lidholm J Phadia AB, Uppsala, Sweden.
- Hoffmann-Sommergruber K Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
- Fernández-Rivas M Allergy Department, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.
- Ballmer-Weber B Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.
- van Ree R Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands; Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address: r.vanree@amc.uva.nl.
- 2015-03-17
Published in:
- The Journal of allergy and clinical immunology. - 2015
EuroPrevall
component-resolved diagnosis
hazelnut allergy
outpatient clinic
Adolescent
Adult
Allergens
Ambulatory Care Facilities
Antigens, Plant
Betula
Carrier Proteins
Corylus
Cross Reactions
Double-Blind Method
Europe
Female
Humans
Immunoglobulin E
Male
Middle Aged
Molecular Epidemiology
Nut Hypersensitivity
Pollen
Skin Tests
English
BACKGROUND
Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens.
OBJECTIVE
Establishing a molecular map of hazelnut allergy across Europe.
METHODS
In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP.
RESULTS
Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen.
CONCLUSIONS
In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established.
Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens.
OBJECTIVE
Establishing a molecular map of hazelnut allergy across Europe.
METHODS
In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP.
RESULTS
Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen.
CONCLUSIONS
In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1016/j.jaci.2014.12.1949
- PMID 25772593
- Persistent URL
- https://sonar.ch/global/documents/251975
Statistics
Document views: 44
File downloads:
- Full-text: 0