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The nuclear pore complex, nuclear transport, and apoptosis.
Journal article

The nuclear pore complex, nuclear transport, and apoptosis.

  • Fahrenkrog B ME Müller Institute for Structural Biology, Biozentrum, University of Basel, Switzerland. birthe.fahrenkrog@unibas.ch
  • 2006-08-12
Published in:
  • Canadian journal of physiology and pharmacology. - 2006
Active Transport, Cell Nucleus
Animals
Apoptosis
Humans
Nuclear Pore
Nuclear Pore Complex Proteins
Nuclear Proteins
English The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm of interphase eukaryotic cells, and it mediates all trafficking between these 2 cellular compartments. As such, the NPC and nuclear transport play central roles in translocating death signals from the cell membrane to the nucleus where they initiate biochemical and morphological changes occurring during apoptosis. Recent findings suggest that the correlation between the NPC, nuclear transport, and apoptosis goes beyond the simple fact that NPCs mediate nuclear transport of key players involved in the cell death program. In this context, the accessibility of key regulators of apoptosis appears to be highly modulated by nuclear transport (e.g., impaired nuclear import might be an apoptotic trigger). In this review, recent findings concerning the unexpected tight link between NPCs, nuclear transport, and apoptosis will be presented and critically discussed.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/252652
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