Journal article

Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles

  • Gregson, John M MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Freitag, Daniel F MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Surendran, Praveen MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Stitziel, Nathan O Departments of Medicine and Genetics, Washington University School of Medicine, St Louis, USA
  • Chowdhury, Rajiv MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Burgess, Stephen MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Kaptoge, Stephen MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Gao, Pei MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Staley, James R MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Willeit, Peter Department of Neurology, Innsbruck Medical University, Austria
  • Nielsen, Sune F Copenhagen University Hospital, University of Copenhagen, Denmark
  • Caslake, Muriel University of Glasgow, UK
  • Trompet, Stella Leiden University Medical Centre, Netherlands
  • Polfus, Linda M University of Texas Health Science Center Houston, USA
  • Kuulasmaa, Kari THL-National Institute for Health and Welfare, Helsinki, Finland
  • Kontto, Jukka THL-National Institute for Health and Welfare, Helsinki, Finland
  • Perola, Markus Department of Health, National Institute for Health and Welfare, Helsinki, Finland
  • Blankenberg, Stefan University Medical Centre Hamburg Eppendorf, Hamburg, Germany
  • Veronesi, Giovanni Research Centre, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
  • Gianfagna, Francesco Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy
  • Männistö, Satu THL-National Institute for Health and Welfare, Helsinki, Finland
  • Kimura, Akinori Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Japan
  • Lin, Honghuang The NHLBI’s Framingham Heart Study, Framingham, USA
  • Reilly, Dermot F Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, USA
  • Gorski, Mathias Department of Nephrology, University Hospital Regensburg, Germany
  • Mijatovic, Vladan Department of Life and Reproduction Sciences, University of Verona, Italy
  • Munroe, Patricia B NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, UK
  • Ehret, Georg B Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
  • Thompson, Alex UCB, Brussels, Belgium
  • Uria-Nickelsen, Maria Clinical Research, Pfizer Worldwide R&D, Cambridge, USA
  • Malarstig, Anders Clinical Research, Pfizer Worldwide R&D, Sollentuna, Sweden
  • Dehghan, Abbas Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands
  • Vogt, Thomas F CHDI Management/CHDI Foundation, Princeton, USA
  • Sasaoka, Taishi Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Japan
  • Takeuchi, Fumihiko Department of Gene Diagnostics and Therapeutics, Research Institute, National Centre for Global Health and Medicine, Tokyo, Japan
  • Kato, Norihiro Department of Gene Diagnostics and Therapeutics, Research Institute, National Centre for Global Health and Medicine, Tokyo, Japan
  • Yamada, Yoshiji Department of Human Functional Genomics, Life Science Research Centre, Mie University, Japan
  • Kee, Frank UKCRC Centre of Excellence for Public Health, Queens University, Belfast, Ireland
  • Müller-Nurasyid, Martina Department of Medicine I, Ludwig-Maximilians-University Munich, Germany
  • Ferrières, Jean Department of Epidemiology, UMR 1027-INSERM, Toulouse University-CHU Toulouse, France
  • Arveiler, Dominique Department of Epidemiology and Public Health, EA 3430, University of Strasbourg and Strasbourg University Hospital, France
  • Amouyel, Philippe Department of Epidemiology and Public Health, Institut Pasteur de Lille, France
  • Salomaa, Veikko THL-National Institute for Health and Welfare, Helsinki, Finland
  • Boerwinkle, Eric Human Genetics Center, University of Texas Health Science Center at Houston, USA
  • Thompson, Simon G MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Ford, Ian University of Glasgow, UK
  • Wouter Jukema, J Leiden University Medical Centre, Netherlands
  • Sattar, Naveed University of Glasgow, UK
  • Packard, Chris J University of Glasgow, UK
  • Shafi Majumder, Abdulla al National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh
  • Alam, Dewan S Centre for Global Health Research, St Michael Hospital, Toronto, Canada
  • Deloukas, Panos William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK
  • Schunkert, Heribert Deutsches Herzzentrum München, Technische Universität München, Germany
  • Samani, Nilesh J Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, UK
  • Kathiresan, Sekar Broad Institute, Cambridge and Massachusetts General Hospital, Boston, USA
  • Nordestgaard, Børge G Copenhagen University Hospital, University of Copenhagen, Denmark
  • Saleheen, Danish University of Pennsylvania, Philadelphia, USA
  • Howson, Joanna MM MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Di Angelantonio, Emanuele MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Butterworth, Adam S MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
  • Danesh, John National Institute of Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
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  • 2016-12-8
Published in:
  • European Journal of Preventive Cardiology. - SAGE Publications. - 2016, vol. 24, no. 5, p. 492-504
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/252744
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