Understanding and Preventing Placenta-Mediated Pregnancy Complications.
- Skeith L Division of Hematology and Hematological Malignancies, Department of Medicine, University of Calgary, Calgary, Canada.
- Blondon M Division of Angiology and Hemostasis, Department of Specialties of Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
- Ní Áinle F Department of Haematology, School of Medicine, University College Dublin, Rotunda Hospital and Mater University Hospital, Irish Network for VTE Research (INViTE), Dublin, Ireland.
- 2020-07-30
Published in:
- Hamostaseologie. - 2020
English
Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evolving. In this narrative review, we will present the latest evidence to better understand hemostatic mechanisms of preeclampsia, as well as in women with placenta-mediated pregnancy complications and inherited thrombophilia or antiphospholipid antibodies. Using four clinical scenarios, the mixed results of preventive efforts through the use of antithrombotic drugs (aspirin, heparin) will be discussed. We will also review knowledge gaps and ongoing research.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1055/a-1184-8388
- PMID 32726830
- Persistent URL
- https://sonar.ch/global/documents/252783
Statistics
Document views: 29
File downloads:
- Full-text: 0