Human leukocyte antigen-G and cancer immunoediting.
- Urosevic M Department of Dermatology, University Hospital Zurich, Zurich, Switzerland. mirjana.urosevic@usz.ch
- Dummer R
- 2008-02-05
Published in:
- Cancer research. - 2008
HLA Antigens
HLA-G Antigens
Histocompatibility Antigens Class I
Humans
Monitoring, Immunologic
Neoplasms
English
Immunosurveillance is an extrinsic mechanism of cancer suppression that eliminates nascent tumors. However, the selection imposed by immunosurveillance can drive tumor evolution and the emergence of clinically apparent neoplasms. Mechanisms of immune escape acquired by less immunogenic variants during this process, termed immunoediting, may contribute significantly to malignant progression. In this review, we summarize the evidence that up-regulation of the nonclassic human leukocyte antigen (HLA) class I molecule HLA-G in tumor cells plays an important role in cancer and immune escape.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1158/0008-5472.CAN-07-2704
- PMID 18245459
- Persistent URL
- https://sonar.ch/global/documents/253413
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