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Effect of respiratory hyperoxic challenge on magnetic susceptibility in human brain assessed by quantitative susceptibility mapping (QSM).
Journal article

Effect of respiratory hyperoxic challenge on magnetic susceptibility in human brain assessed by quantitative susceptibility mapping (QSM).

  • Özbay PS University Hospital Zurich and University of Zurich, Institute of Diagnostic and Interventional Radiology, Zurich, Switzerland.
  • Rossi C University Hospital Zurich and University of Zurich, Institute of Diagnostic and Interventional Radiology, Zurich, Switzerland.
  • Kocian R University Hospital Zurich, Institute of Anesthesiology, Zurich, Switzerland.
  • Redle M University Hospital Zurich and University of Zurich, Institute of Diagnostic and Interventional Radiology, Zurich, Switzerland.
  • Boss A University Hospital Zurich and University of Zurich, Institute of Diagnostic and Interventional Radiology, Zurich, Switzerland.
  • Pruessmann KP University of Zurich and ETH Zürich, Institute for Biomedical Engineering, Zurich, Switzerland.
  • Nanz D University Hospital Zurich and University of Zurich, Institute of Diagnostic and Interventional Radiology, Zurich, Switzerland.
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  • 2015-10-21
Published in:
  • NMR in biomedicine. - 2015
BOLD
R2* quantification
hyperoxia
magnetic susceptibility
oxygenation
quantitative susceptibility mapping
Administration, Inhalation
Adult
Brain
Female
Humans
Hyperoxia
Image Interpretation, Computer-Assisted
Magnetic Resonance Angiography
Male
Middle Aged
Oximetry
Oxygen
Reproducibility of Results
Sensitivity and Specificity
Tissue Distribution
Young Adult
English The purpose of this study was to measure the regional change of magnetic susceptibility in human brain upon inhalation of 100% oxygen by MRI quantitative susceptibility mapping (QSM). Fourteen healthy volunteers were scanned in a 3 T MR scanner with a 3D multi-gradient-echo sequence while breathing medical air (normoxia) and pure oxygen (hyperoxia). QSM images and R2* maps were calculated. Mean susceptibility differences versus white matter were measured in regions of interest covering veins, gray matter (GM), and cerebrospinal fluid (CSF) under both conditions. Hyperoxia resulted in a strong susceptibility decrease in large veins (-154.4 ± 65.9 ppb, p < 10(-6)), in a smaller reduction in GM (-1.3 ± 1 ppb, p < 0.001), and in a susceptibility increase in ventricular CSF (3.8 ± 1.8 ppb, p < 10(-5)). The susceptibility decrease in veins implied an increase of venous oxygen saturation (SvO2) by 10.1 ± 4.0%. Compared with QSM, R2* was more seriously affected by long-distance effects not related to local tissue oxygenation and increased in cerebral frontal regions (3 ± 2 s(-1), p < 0.0004) due to paramagnetic molecular oxygen in cavities. The results highlight the potential of QSM to yield region-specific quantitative oxygenation information, and, thus, for applications such as oxygen-therapy monitoring or identification of hypoxic tumor tissue during radiotherapy planning.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/253842
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