Journal article
Effect of the Inclusion of the Metacarpophalangeal Joints on the Wrist Magnetic Resonance Imaging Scoring System in Juvenile Idiopathic Arthritis.
- van Dijkhuizen EHP From the Clinica Pediatrica e Reumatologia, and the Department of Pediatric Radiology, Istituto Giannina Gaslini, Genoa, Italy; Pediatric Rheumatology, Universitair Medisch Centrum (UMC) Utrecht, Wilhelmina Children's Hospital, Utrecht, the Netherlands; Unité romande de rhumatologie pédiatrique, Centre Hospitalier Universitaire Vaudois, Lausanne; Pediatric Department of Southern Switzerland, Bellinzona, Switzerland; Department of Pediatric Radiology, Haukeland University Hospital and Department of Clinical Medicine, Bergen, Norway; Department of Pediatric Rheumatology, Amsterdam Rheumatology and Immunology Center Reade, Amsterdam, the Netherlands; Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli studi di Genova, Genoa, Italy.
- Vanoni F From the Clinica Pediatrica e Reumatologia, and the Department of Pediatric Radiology, Istituto Giannina Gaslini, Genoa, Italy; Pediatric Rheumatology, Universitair Medisch Centrum (UMC) Utrecht, Wilhelmina Children's Hospital, Utrecht, the Netherlands; Unité romande de rhumatologie pédiatrique, Centre Hospitalier Universitaire Vaudois, Lausanne; Pediatric Department of Southern Switzerland, Bellinzona, Switzerland; Department of Pediatric Radiology, Haukeland University Hospital and Department of Clinical Medicine, Bergen, Norway; Department of Pediatric Rheumatology, Amsterdam Rheumatology and Immunology Center Reade, Amsterdam, the Netherlands; Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli studi di Genova, Genoa, Italy.
- Magnano GM From the Clinica Pediatrica e Reumatologia, and the Department of Pediatric Radiology, Istituto Giannina Gaslini, Genoa, Italy; Pediatric Rheumatology, Universitair Medisch Centrum (UMC) Utrecht, Wilhelmina Children's Hospital, Utrecht, the Netherlands; Unité romande de rhumatologie pédiatrique, Centre Hospitalier Universitaire Vaudois, Lausanne; Pediatric Department of Southern Switzerland, Bellinzona, Switzerland; Department of Pediatric Radiology, Haukeland University Hospital and Department of Clinical Medicine, Bergen, Norway; Department of Pediatric Rheumatology, Amsterdam Rheumatology and Immunology Center Reade, Amsterdam, the Netherlands; Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli studi di Genova, Genoa, Italy.
- Magnaguagno F From the Clinica Pediatrica e Reumatologia, and the Department of Pediatric Radiology, Istituto Giannina Gaslini, Genoa, Italy; Pediatric Rheumatology, Universitair Medisch Centrum (UMC) Utrecht, Wilhelmina Children's Hospital, Utrecht, the Netherlands; Unité romande de rhumatologie pédiatrique, Centre Hospitalier Universitaire Vaudois, Lausanne; Pediatric Department of Southern Switzerland, Bellinzona, Switzerland; Department of Pediatric Radiology, Haukeland University Hospital and Department of Clinical Medicine, Bergen, Norway; Department of Pediatric Rheumatology, Amsterdam Rheumatology and Immunology Center Reade, Amsterdam, the Netherlands; Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli studi di Genova, Genoa, Italy.
- Rosendahl K From the Clinica Pediatrica e Reumatologia, and the Department of Pediatric Radiology, Istituto Giannina Gaslini, Genoa, Italy; Pediatric Rheumatology, Universitair Medisch Centrum (UMC) Utrecht, Wilhelmina Children's Hospital, Utrecht, the Netherlands; Unité romande de rhumatologie pédiatrique, Centre Hospitalier Universitaire Vaudois, Lausanne; Pediatric Department of Southern Switzerland, Bellinzona, Switzerland; Department of Pediatric Radiology, Haukeland University Hospital and Department of Clinical Medicine, Bergen, Norway; Department of Pediatric Rheumatology, Amsterdam Rheumatology and Immunology Center Reade, Amsterdam, the Netherlands; Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli studi di Genova, Genoa, Italy.
- van Rossum MA From the Clinica Pediatrica e Reumatologia, and the Department of Pediatric Radiology, Istituto Giannina Gaslini, Genoa, Italy; Pediatric Rheumatology, Universitair Medisch Centrum (UMC) Utrecht, Wilhelmina Children's Hospital, Utrecht, the Netherlands; Unité romande de rhumatologie pédiatrique, Centre Hospitalier Universitaire Vaudois, Lausanne; Pediatric Department of Southern Switzerland, Bellinzona, Switzerland; Department of Pediatric Radiology, Haukeland University Hospital and Department of Clinical Medicine, Bergen, Norway; Department of Pediatric Rheumatology, Amsterdam Rheumatology and Immunology Center Reade, Amsterdam, the Netherlands; Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli studi di Genova, Genoa, Italy.
- Martini A From the Clinica Pediatrica e Reumatologia, and the Department of Pediatric Radiology, Istituto Giannina Gaslini, Genoa, Italy; Pediatric Rheumatology, Universitair Medisch Centrum (UMC) Utrecht, Wilhelmina Children's Hospital, Utrecht, the Netherlands; Unité romande de rhumatologie pédiatrique, Centre Hospitalier Universitaire Vaudois, Lausanne; Pediatric Department of Southern Switzerland, Bellinzona, Switzerland; Department of Pediatric Radiology, Haukeland University Hospital and Department of Clinical Medicine, Bergen, Norway; Department of Pediatric Rheumatology, Amsterdam Rheumatology and Immunology Center Reade, Amsterdam, the Netherlands; Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli studi di Genova, Genoa, Italy.
- Malattia C From the Clinica Pediatrica e Reumatologia, and the Department of Pediatric Radiology, Istituto Giannina Gaslini, Genoa, Italy; Pediatric Rheumatology, Universitair Medisch Centrum (UMC) Utrecht, Wilhelmina Children's Hospital, Utrecht, the Netherlands; Unité romande de rhumatologie pédiatrique, Centre Hospitalier Universitaire Vaudois, Lausanne; Pediatric Department of Southern Switzerland, Bellinzona, Switzerland; Department of Pediatric Radiology, Haukeland University Hospital and Department of Clinical Medicine, Bergen, Norway; Department of Pediatric Rheumatology, Amsterdam Rheumatology and Immunology Center Reade, Amsterdam, the Netherlands; Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili, Università degli studi di Genova, Genoa, Italy. claramalattia@gaslini.org.
- 2018-08-17
Published in:
- The Journal of rheumatology. - 2018
JUVENILE IDIOPATHIC ARTHRITIS
MAGNETIC RESONANCE IMAGING
METACARPOPHALANGEAL JOINTS
PATIENT OUTCOME ASSESSMENT
RELIABILITY AND VALIDITY
Arthritis, Juvenile
Female
Humans
Magnetic Resonance Imaging
Male
Metacarpophalangeal Joint
Reproducibility of Results
Severity of Illness Index
Wrist
English
OBJECTIVE
To extend the magnetic resonance imaging (MRI) score for assessment of wrist synovitis in juvenile idiopathic arthritis (JIA) by inclusion of the metacarpophalangeal (MCP) joints, and to compare the metric properties of the original and the extended score.
METHODS
Wrist MRI of 70 patients with JIA were scored by 3 independent readers according to (1) the wrist component of the rheumatoid arthritis MRI synovitis score (comprising distal radioulnar, radiocarpal, and combined midcarpal and carpometacarpal joints); and (2) an extended score including the MCP joints. Thirty-eight patients had a 1-year MRI followup. The concordance between the readers [intraclass correlation coefficient (ICC), 95% limits of agreement (LOA), and weighted Cohen's κ], correlations with clinical variables (Spearman's ϱ), and the sensitivity to change [standardized response mean (SRM)] were calculated for both scores.
RESULTS
The interreader agreement was moderate for the original score (ICC 0.77; 95% CI 0.68-0.84) and good for the extended score (ICC 0.86; 95% CI 0.80-0.91). Using 95% LOA, the aggregate score variability was less favorable with relatively wide LOA. Weighted Cohen's κ of the individual joints indicated good agreement for the original score and good to excellent agreement for the extended score. Correlations with clinical variables reflecting disease activity improved for the extended score and its SRM was higher compared to that of the original score.
CONCLUSION
The extended score showed better reliability, construct validity, and sensitivity to change than the original. Inclusion of the MCP joints should be considered for a more accurate assessment of disease activity and treatment efficacy in JIA.
To extend the magnetic resonance imaging (MRI) score for assessment of wrist synovitis in juvenile idiopathic arthritis (JIA) by inclusion of the metacarpophalangeal (MCP) joints, and to compare the metric properties of the original and the extended score.
METHODS
Wrist MRI of 70 patients with JIA were scored by 3 independent readers according to (1) the wrist component of the rheumatoid arthritis MRI synovitis score (comprising distal radioulnar, radiocarpal, and combined midcarpal and carpometacarpal joints); and (2) an extended score including the MCP joints. Thirty-eight patients had a 1-year MRI followup. The concordance between the readers [intraclass correlation coefficient (ICC), 95% limits of agreement (LOA), and weighted Cohen's κ], correlations with clinical variables (Spearman's ϱ), and the sensitivity to change [standardized response mean (SRM)] were calculated for both scores.
RESULTS
The interreader agreement was moderate for the original score (ICC 0.77; 95% CI 0.68-0.84) and good for the extended score (ICC 0.86; 95% CI 0.80-0.91). Using 95% LOA, the aggregate score variability was less favorable with relatively wide LOA. Weighted Cohen's κ of the individual joints indicated good agreement for the original score and good to excellent agreement for the extended score. Correlations with clinical variables reflecting disease activity improved for the extended score and its SRM was higher compared to that of the original score.
CONCLUSION
The extended score showed better reliability, construct validity, and sensitivity to change than the original. Inclusion of the MCP joints should be considered for a more accurate assessment of disease activity and treatment efficacy in JIA.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.3899/jrheum.171246
- PMID 30111639
- Persistent URL
- https://sonar.ch/global/documents/25420
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