Renal arteriovenous oxygen shunting.
- Kuo W aThe Interface Group, Institute of Physiology, University of Zurich bNational Center of Competence in Research, Kidney.CH cZurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
- Kurtcuoglu V
- 2017-04-12
Published in:
- Current opinion in nephrology and hypertension. - 2017
Carbon Dioxide
Humans
Hypoxia
Kidney
Kidney Diseases
Kidney Glomerulus
Oxygen
Oxygen Consumption
Renal Artery
Renal Circulation
Renal Veins
English
PURPOSE OF REVIEW
Renal arteriovenous oxygen shunting has been proposed as a mechanism by which oxygen supplied to the kidney can bypass the renal parenchyma. Shunting could, therefore, play a crucial role in renal hypoxia and hyperoxia. In the absence of suitable quantitative experimental methods, computational modeling has been employed in recent years to estimate the extent and potential impact of oxygen shunting.
RECENT FINDINGS
Overestimation of the separation distance between arteries and veins was suggested to be responsible for previous findings that only negligible amounts of oxygen are shunted in the preglomerular vasculature. However, models considering the correct separation distance and wrapping of artery-vein pairs still showed shunting at negligible levels of less than 1% of total renal oxygen delivery. The effect of reverse CO2 shunting on the oxygen-hemoglobin dissociation curve was found to impair, rather than promote, preglomerular oxygen shunting.
SUMMARY
Oxygen is unlikely to be shunted along the preglomerular vasculature in sufficient quantities to affect renal oxygenation. There may be substantial shunting at the level of the postglomerular vasculature, but more extensive efforts in structural imaging and computational modeling are needed to quantify it reliably.
Renal arteriovenous oxygen shunting has been proposed as a mechanism by which oxygen supplied to the kidney can bypass the renal parenchyma. Shunting could, therefore, play a crucial role in renal hypoxia and hyperoxia. In the absence of suitable quantitative experimental methods, computational modeling has been employed in recent years to estimate the extent and potential impact of oxygen shunting.
RECENT FINDINGS
Overestimation of the separation distance between arteries and veins was suggested to be responsible for previous findings that only negligible amounts of oxygen are shunted in the preglomerular vasculature. However, models considering the correct separation distance and wrapping of artery-vein pairs still showed shunting at negligible levels of less than 1% of total renal oxygen delivery. The effect of reverse CO2 shunting on the oxygen-hemoglobin dissociation curve was found to impair, rather than promote, preglomerular oxygen shunting.
SUMMARY
Oxygen is unlikely to be shunted along the preglomerular vasculature in sufficient quantities to affect renal oxygenation. There may be substantial shunting at the level of the postglomerular vasculature, but more extensive efforts in structural imaging and computational modeling are needed to quantify it reliably.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1097/MNH.0000000000000332
- PMID 28399018
- Persistent URL
- https://sonar.ch/global/documents/259604
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