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Journal article

Tim-3, Lag-3, and TIGIT.

  • Joller N Institute for Experimental Immunology, University of Zurich, Zurich, Switzerland.
  • Kuchroo VK Harvard Medical School and Brigham & Women's Hospital, Evergrande Center for Immunologic Diseases, Boston, MA, USA. vkuchroo@evergrande.hms.harvard.edu.
  • 2017-09-14
Published in:
  • Current topics in microbiology and immunology. - 2017
Animals
Antigens, CD
Autoimmunity
Hepatitis A Virus Cellular Receptor 2
Humans
Immune Tolerance
Mice
Neoplasms
Receptors, Immunologic
T-Lymphocytes
English Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against tumors or persistent pathogens. T cells express a module of co-inhibitory receptors, which display great diversity in expression, structure, and function. Here, we focus on the co-inhibitory receptors Tim-3, Lag-3, and TIGIT and how they regulate T cell function, maintenance of self-tolerance, their role in regulating ongoing T cell responses at peripheral tissues, and their synergistic effects in regulating autoimmunity and antitumor responses.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.ch/global/documents/259896
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