Journal article
Does parental farm upbringing influence the risk of asthma in offspring? A three-generation study.
- Timm S Department of Public Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.
- Svanes C Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
- Frydenberg M Department of Public Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.
- Sigsgaard T Department of Public Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.
- Holm M Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
- Janson C Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
- Bråbäck L Section of Sustainable Health, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
- Campbell B Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, Australia.
- Kjaer Madsen M Department of Public Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.
- Jõgi NO Department of Clinical Science, University of Bergen, Bergen, Norway.
- Jõgi R Tartu University Hospital, Lung Clinic, Tartu, Estonia.
- Schiöler L Section of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
- Bertelsen RJ Institute of Clinical Science, University of Bergen, Bergen, Norway.
- Johannessen A Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
- Sanchez-Ramos JL Department of Nursing, University of Huelva, Huelva, Spain.
- Martinez-Moretalla J Department of Internal Medicine, Albacete University Hospital, Albacete, Spain.
- Dratva J ZHAW School of Health Professions, Winterthur, Switzerland.
- Dharmage S Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, Australia.
- Schlünssen V Department of Public Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.
- 2020-08-05
Published in:
- International journal of epidemiology. - 2020
English
BACKGROUND
A farm upbringing has been associated with lower risk of asthma and methylation of asthma-related genes. As such, a farm upbringing has the potential to transfer asthma risk across generations, but this has never been investigated. We aimed to study the generational effects from a parental farm upbringing on offspring asthma.
METHODS
Our study involved three generations: 5759 participants from the European Community Respiratory Health Survey (ECRHS) study (born 1945-1971, denoted G1), their 9991 parents (G0) and their 8260 offspring (G2) participating in RHINESSA (Respiratory Health In Northern Europe, Spain and Australia). Questionnaire data were collected on G0 and G1 from G1 in 2010 and on G2 from themselves in 2013. The parental/grandparental place of upbringing was categorized: (i) both parents from farm; (ii) mother from farm, father from village/city; (iii) father from farm, mother from village/city; (iv) both parents from village or one parent from village and one from city; (v) both parents from city (reference group). Grandparental upbringing was equivalently categorized. Offspring asthma was self-reported and data were analysed using Cox-regression models with G2 age as the time scale.
RESULTS
A parental farm upbringing was not associated with offspring asthma when compared with city upbringing [hazard ratio (HR) 1.12, 95% confidence interval (CI) 0.74-1.69]. Findings remained similar when stratified by offspring upbringing and asthma phenotypes. Quantitative bias analyses showed similar estimates for alternative data sources. A grandparental farm upbringing was not associated with offspring asthma in either the maternal (HR 1.05, 95% CI 0.67-1.65) or paternal line (HR 1.02, 95% CI 0.62-1.68).
CONCLUSIONS
This multigenerational analysis suggests no evidence of an association between parental/grandparental farm upbringing and offspring asthma.
A farm upbringing has been associated with lower risk of asthma and methylation of asthma-related genes. As such, a farm upbringing has the potential to transfer asthma risk across generations, but this has never been investigated. We aimed to study the generational effects from a parental farm upbringing on offspring asthma.
METHODS
Our study involved three generations: 5759 participants from the European Community Respiratory Health Survey (ECRHS) study (born 1945-1971, denoted G1), their 9991 parents (G0) and their 8260 offspring (G2) participating in RHINESSA (Respiratory Health In Northern Europe, Spain and Australia). Questionnaire data were collected on G0 and G1 from G1 in 2010 and on G2 from themselves in 2013. The parental/grandparental place of upbringing was categorized: (i) both parents from farm; (ii) mother from farm, father from village/city; (iii) father from farm, mother from village/city; (iv) both parents from village or one parent from village and one from city; (v) both parents from city (reference group). Grandparental upbringing was equivalently categorized. Offspring asthma was self-reported and data were analysed using Cox-regression models with G2 age as the time scale.
RESULTS
A parental farm upbringing was not associated with offspring asthma when compared with city upbringing [hazard ratio (HR) 1.12, 95% confidence interval (CI) 0.74-1.69]. Findings remained similar when stratified by offspring upbringing and asthma phenotypes. Quantitative bias analyses showed similar estimates for alternative data sources. A grandparental farm upbringing was not associated with offspring asthma in either the maternal (HR 1.05, 95% CI 0.67-1.65) or paternal line (HR 1.02, 95% CI 0.62-1.68).
CONCLUSIONS
This multigenerational analysis suggests no evidence of an association between parental/grandparental farm upbringing and offspring asthma.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1093/ije/dyaa091
- PMID 32747948
- Persistent URL
- https://sonar.ch/global/documents/260304
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