Journal article
Age-Related Variations in Takotsubo Syndrome.
- Cammann VL University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
- Szawan KA University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
- Stähli BE University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
- Kato K University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
- Budnik M Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
- Wischnewsky M FB Mathematics and Computer Science, University of Bremen, Bremen, Germany.
- Dreiding S University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
- Levinson RA University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
- Di Vece D University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
- Gili S Centro cardiologico Monzino, IRCCS, Milan, Italy.
- Citro R Heart Department, University Hospital "San Giovanni di Dio e Ruggi d'Aragona," Salerno, Italy.
- Bossone E Division of Cardiology, "Antonio Cardarelli" Hospital, Naples, Italy.
- Neuhaus M Department of Cardiology, Kantonsspital Frauenfeld, Frauenfeld, Switzerland.
- Franke J Department of Cardiology, Heidelberg University Hospital, Heidelberg, Germany.
- Meder B Department of Cardiology, Heidelberg University Hospital, Heidelberg, Germany.
- Jaguszewski M First Department of Cardiology, Medical University of Gdansk, Gdansk, Poland.
- Noutsias M Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
- Knorr M Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
- Heiner S Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
- D'Ascenzo F Division of Cardiology, Department of Medical Sciences, AOU Città della Salute e della Scienza, University of Turin, Turin, Italy.
- Dichtl W University Hospital for Internal Medicine III (Cardiology and Angiology), Medical University Innsbruck, Innsbruck, Austria.
- Burgdorf C Heart and Vascular Centre Bad Bevensen, Bad Bevensen, Germany.
- Kherad B Department of Cardiology, Charité, Campus Rudolf Virchow, Berlin, Germany.
- Tschöpe C Department of Cardiology, Charité, Campus Rudolf Virchow, Berlin, Germany.
- Sarcon A Section of Cardiac Electrophysiology, Department of Medicine, University of California-San Francisco, San Francisco, California.
- Shinbane J University of Southern California, Keck School of Medicine, Los Angeles, California.
- Rajan L TJ Health Partners Heart and Vascular, Glasgow, Kentucky.
- Michels G Department of Internal Medicine III, Heart Center University of Cologne, Cologne, Germany.
- Pfister R Department of Internal Medicine III, Heart Center University of Cologne, Cologne, Germany.
- Cuneo A Krankenhaus "Maria Hilf" Medizinische Klinik, Stadtlohn, Germany.
- Jacobshagen C Clinic for Cardiology and Pneumology, Georg August University Goettingen, Goettingen, Germany.
- Karakas M Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, Hamburg, Germany.
- Koenig W Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
- Pott A Department of Internal Medicine II-Cardiology, University of Ulm, Medical Center, Ulm, Germany.
- Meyer P Service de cardiologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
- Roffi M Service de cardiologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
- Banning A Department of Cardiology, John Radcliffe Hospital, Oxford University Hospitals, Oxford, United Kingdom.
- Wolfrum M Department of Internal Medicine, Cardiology and Angiology, Magdeburg University, Magdeburg, Germany.
- Cuculi F Department of Cardiology, Kantonsspital Lucerne, Lucerne, Switzerland.
- Kobza R Department of Cardiology, Kantonsspital Lucerne, Lucerne, Switzerland.
- Fischer TA Department of Cardiology, Kantonsspital Winterthur, Winterthur, Switzerland.
- Vasankari T Heart Center, Turku University Hospital and University of Turku, Turku, Finland.
- Airaksinen KEJ Heart Center, Turku University Hospital and University of Turku, Turku, Finland.
- Napp LC Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
- Dworakowski R Department of Cardiology, King's College Hospital, London, United Kingdom.
- MacCarthy P Department of Cardiology, King's College Hospital, London, United Kingdom.
- Kaiser C Department of Cardiology, University Hospital Basel, Basel, Switzerland.
- Osswald S Department of Cardiology, University Hospital Basel, Basel, Switzerland.
- Galiuto L Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
- Chan C Department of Cardiology, Christchurch Hospital, Christchurch, New Zealand.
- Bridgman P Department of Cardiology, Christchurch Hospital, Christchurch, New Zealand.
- Beug D Department of Cardiology and Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
- Delmas C Department of Cardiology and Cardiac Imaging Center, University Hospital of Rangueil, Toulouse, France.
- Lairez O Department of Cardiology and Cardiac Imaging Center, University Hospital of Rangueil, Toulouse, France.
- Gilyarova E Intensive Coronary Care Unit, Moscow City Hospital #1 named after N. Pirogov, Moscow, Russia.
- Shilova A Intensive Coronary Care Unit, Moscow City Hospital #1 named after N. Pirogov, Moscow, Russia.
- Gilyarov M Intensive Coronary Care Unit, Moscow City Hospital #1 named after N. Pirogov, Moscow, Russia.
- El-Battrawy I First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM) University of Heidelberg, Mannheim, Germany; DZHK (German Center for Cardiovascular Research), partner site, Heidelberg-Mannheim, Mannheim, Germany.
- Akin I First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM) University of Heidelberg, Mannheim, Germany; DZHK (German Center for Cardiovascular Research), partner site, Heidelberg-Mannheim, Mannheim, Germany.
- Poledniková K Cardiocenter, Third Faculty of Medicine, Charles University in Prague and University Hospital Královské Vinohrady, Prague, Czech Republic.
- Toušek P Cardiocenter, Third Faculty of Medicine, Charles University in Prague and University Hospital Královské Vinohrady, Prague, Czech Republic.
- Winchester DE Division of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida.
- Galuszka J Department of Internal Medicine I - Cardiology, University Hospital Olomouc, Olomouc, Czech Republic.
- Ukena C Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.
- Poglajen G Advanced Heart Failure and Transplantation Center, University Medical Center Ljubljana, Ljubljana, Slovenia.
- Carrilho-Ferreira P Santa Maria University Hospital, CHULN, Center of Cardiology of the University of Lisbon, Lisbon School of Medicine, Lisbon Academic Medical Center, Lisboa, Portugal.
- Hauck C Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany.
- Paolini C Local Health Unit n.8, Cardiology Unit, Arzignano, Vicenza, Italy.
- Bilato C Local Health Unit n.8, Cardiology Unit, Arzignano, Vicenza, Italy.
- Kobayashi Y Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
- Shoji T Department of Cardiology, Chiba Emergency Medical Center, Chiba, Japan.
- Ishibashi I Department of Cardiology, Chiba Emergency Medical Center, Chiba, Japan.
- Takahara M Division of Cardiology, Kimitsu Central Hospital, Kisarazu, Japan.
- Himi T Division of Cardiology, Kimitsu Central Hospital, Kisarazu, Japan.
- Din J Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, United Kingdom.
- Al-Shammari A Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, United Kingdom.
- Prasad A Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
- Rihal CS Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
- Liu K Division of Cardiology, Heart and Vascular Center, University of Iowa, Iowa City, Iowa.
- Schulze PC Department of Internal Medicine I, University Hospital Jena, Friedrich-Schiller-University Jena, Jena, Germany.
- Bianco M Division of Cardiology, A.O.U San Luigi Gonzaga, Orbassano, Turin, Italy.
- Jörg L Department of Cardiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
- Rickli H Department of Cardiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
- Pestana G Department of Cardiology, Centro Hospitalar Universitário de São João, E.P.E., Porto, Portugal.
- Nguyen TH Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, South Australia, Australia.
- Böhm M Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.
- Maier LS Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany.
- Pinto FJ Santa Maria University Hospital, CHULN, Center of Cardiology of the University of Lisbon, Lisbon School of Medicine, Lisbon Academic Medical Center, Lisboa, Portugal.
- Widimský P Cardiocenter, Third Faculty of Medicine, Charles University in Prague and University Hospital Královské Vinohrady, Prague, Czech Republic.
- Felix SB Department of Cardiology and Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
- Braun-Dullaeus RC Department of Internal Medicine, Cardiology and Angiology, Magdeburg University, Magdeburg, Germany.
- Rottbauer W Department of Internal Medicine II-Cardiology, University of Ulm, Medical Center, Ulm, Germany.
- Hasenfuß G Clinic for Cardiology and Pneumology, Georg August University Goettingen, Goettingen, Germany.
- Pieske BM Department of Cardiology, Charité, Campus Rudolf Virchow, Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin Institute of Health (BIH), Berlin, Germany.
- Schunkert H Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany; Local Health Unit n.8, Cardiology Unit, Arzignano, Vicenza, Italy.
- Borggrefe M First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM) University of Heidelberg, Mannheim, Germany; DZHK (German Center for Cardiovascular Research), partner site, Heidelberg-Mannheim, Mannheim, Germany.
- Thiele H Heart Center Leipzig - University Hospital, Department of Internal Medicine/Cardiology, Leipzig, Germany.
- Bauersachs J Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
- Katus HA Department of Cardiology, Heidelberg University Hospital, Heidelberg, Germany.
- Horowitz JD Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, South Australia, Australia.
- Di Mario C Structural Interventional Cardiology, Careggi University Hospital, Florence, Italy.
- Münzel T Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
- Crea F Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
- Bax JJ Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.
- Lüscher TF Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Zurich, Switzerland; Royal Brompton and Harefield Hospitals Trust and Imperial College, London, United Kingdom.
- Ruschitzka F University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
- Ghadri JR University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
- Opolski G Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
- Templin C University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland. Electronic address: Christian.Templin@usz.ch.
- 2020-04-25
Published in:
- Journal of the American College of Cardiology. - 2020
English
BACKGROUND
Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients.
OBJECTIVES
This study aimed to investigate age-related differences in TTS.
METHODS
Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as well as short- and long-term mortality were compared among groups.
RESULTS
Of 2,098 TTS patients, 242 (11.5%) patients were ≤50 years of age, 1,194 (56.9%) were 51 to 74 years of age, and 662 (31.6%) were ≥75 years of age. Younger patients were more often men (12.4% vs. 10.9% vs. 6.3%; p = 0.002) and had an increased prevalence of acute neurological (16.3% vs. 8.4% vs. 8.8%; p = 0.001) or psychiatric disorders (14.1% vs. 10.3% vs. 5.6%; p < 0.001) compared with middle-aged and elderly TTS patients. Furthermore, younger patients had more often cardiogenic shock (15.3% vs. 9.1% vs. 8.1%; p = 0.004) and had a numerically higher in-hospital mortality (6.6% vs. 3.6% vs. 5.1%; p = 0.07). At multivariable analysis, younger (odds ratio: 1.60; 95% confidence interval: 0.86 to 3.01; p = 0.14) and older age (odds ratio: 1.09; 95% confidence interval: 0.66 to 1.80; p = 0.75) were not independently associated with in-hospital mortality using the middle-aged group as a reference. There were no differences in 60-day mortality rates among groups.
CONCLUSIONS
A substantial proportion of TTS patients are younger than 50 years of age. TTS is associated with severe complications requiring intensive care, particularly in younger patients.
Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients.
OBJECTIVES
This study aimed to investigate age-related differences in TTS.
METHODS
Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as well as short- and long-term mortality were compared among groups.
RESULTS
Of 2,098 TTS patients, 242 (11.5%) patients were ≤50 years of age, 1,194 (56.9%) were 51 to 74 years of age, and 662 (31.6%) were ≥75 years of age. Younger patients were more often men (12.4% vs. 10.9% vs. 6.3%; p = 0.002) and had an increased prevalence of acute neurological (16.3% vs. 8.4% vs. 8.8%; p = 0.001) or psychiatric disorders (14.1% vs. 10.3% vs. 5.6%; p < 0.001) compared with middle-aged and elderly TTS patients. Furthermore, younger patients had more often cardiogenic shock (15.3% vs. 9.1% vs. 8.1%; p = 0.004) and had a numerically higher in-hospital mortality (6.6% vs. 3.6% vs. 5.1%; p = 0.07). At multivariable analysis, younger (odds ratio: 1.60; 95% confidence interval: 0.86 to 3.01; p = 0.14) and older age (odds ratio: 1.09; 95% confidence interval: 0.66 to 1.80; p = 0.75) were not independently associated with in-hospital mortality using the middle-aged group as a reference. There were no differences in 60-day mortality rates among groups.
CONCLUSIONS
A substantial proportion of TTS patients are younger than 50 years of age. TTS is associated with severe complications requiring intensive care, particularly in younger patients.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.jacc.2020.02.057
- PMID 32327096
- Persistent URL
- https://sonar.ch/global/documents/260720
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