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EANM/EARL harmonization strategies in PET quantification: from daily practice to multicentre oncological studies.

  • Aide N Nuclear Medicine Department, University Hospital, Caen, France. aide-n@chu-caen.fr.
  • Lasnon C Inserm U1086 ANTICIPE, Caen University, Caen, France.
  • Veit-Haibach P Department of Nuclear Medicine and Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland.
  • Sera T Nuclear Medicine Department, University of Szeged, Szeged, Hungary.
  • Sattler B Department of Nuclear Medicine, University Hospital of Leipzig, 04103, Leipzig, Germany.
  • Boellaard R Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
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  • 2017-06-18
Published in:
  • European journal of nuclear medicine and molecular imaging. - 2017
Deauville score
EARL accreditation
EORTC
Harmonization
MATV
PERCIST
PET/CT
SUV
Humans
Magnetic Resonance Imaging
Multicenter Studies as Topic
Neoplasms
Positron-Emission Tomography
Reference Standards
Societies, Medical
English Quantitative positron emission tomography/computed tomography (PET/CT) can be used as diagnostic or prognostic tools (i.e. single measurement) or for therapy monitoring (i.e. longitudinal studies) in multicentre studies. Use of quantitative parameters, such as standardized uptake values (SUVs), metabolic active tumor volumes (MATVs) or total lesion glycolysis (TLG), in a multicenter setting requires that these parameters be comparable among patients and sites, regardless of the PET/CT system used. This review describes the motivations and the methodologies for quantitative PET/CT performance harmonization with emphasis on the EANM Research Ltd. (EARL) Fluorodeoxyglucose (FDG) PET/CT accreditation program, one of the international harmonization programs aiming at using FDG PET as a quantitative imaging biomarker. In addition, future accreditation initiatives will be discussed. The validation of the EARL accreditation program to harmonize SUVs and MATVs is described in a wide range of tumor types, with focus on therapy assessment using either the European Organization for Research and Treatment of Cancer (EORTC) criteria or PET Evaluation Response Criteria in Solid Tumors (PERCIST), as well as liver-based scales such as the Deauville score. Finally, also presented in this paper are the results from a survey across 51 EARL-accredited centers reporting how the program was implemented and its impact on daily routine and in clinical trials, harmonization of new metrics such as MATV and heterogeneity features.
Language
  • English
Open access status
hybrid
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https://sonar.ch/global/documents/260943
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