Back
Full-text
Journal article

Evaluation of the In Vivo Activity of Tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini

  • Keiser, Jennifer Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland
  • Shu-Hua, Xiao National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, People's Republic of China
  • Chollet, Jacques Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland
  • Tanner, Marcel Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland
  • Utzinger, Jürg Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland
Show more…
Published in:
  • Antimicrobial Agents and Chemotherapy. - American Society for Microbiology. - 2006, vol. 51, no. 3, p. 1096-1098
Pharmacology (medical)
Pharmacology
Infectious Diseases
English ABSTRACT
We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/261081
Statistics
Document views: 17 File downloads:
  • fulltext.pdf: 0