Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes.
- van Coevorden-Hameete MH Cell Biology Department of Biology Faculty of Science Utrecht University Padualaan 83584 CH Utrecht The Netherlands.
- van Beuningen SFB Cell Biology Department of Biology Faculty of Science Utrecht University Padualaan 83584 CH Utrecht The Netherlands.
- Perrenoud M Service of Neurology Centre Hospitalier Universitaire Vaudois (CHUV) Chemin du Mont-Paisible 16CH 1011 Lausanne Switzerland.
- Will LM Cell Biology Department of Biology Faculty of Science Utrecht University Padualaan 83584 CH Utrecht The Netherlands.
- Hulsenboom E Department of Neurology Erasmus University Medical Center Dr. Molewaterplein 403015 GD Rotterdam The Netherlands.
- Demonet JF Leenaards Memory Centre Department of Clinical Neurosciences Centre Hospitalier Universitaire Vaudois (CHUV) Chemin du Mont-Paisible 16CH 1011 Lausanne Switzerland.
- Sabater L Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS) Carrer del Rosselló 14908036 Barcelona Spain.
- Kros JM Department of Pathology Erasmus University Medical Center Dr. Molewaterplein 403015 GD Rotterdam The Netherlands.
- Verschuuren JJGM Department of Neurology Leiden University Medical Center Albinusdreef 22333 ZA Leiden The Netherlands.
- Titulaer MJ Department of Neurology Erasmus University Medical Center Dr. Molewaterplein 403015 GD Rotterdam The Netherlands.
- de Graaff E Cell Biology Department of Biology Faculty of Science Utrecht University Padualaan 83584 CH Utrecht The Netherlands.
- Sillevis Smitt PAE Department of Neurology Erasmus University Medical Center Dr. Molewaterplein 403015 GD Rotterdam The Netherlands.
- Hoogenraad CC Cell Biology Department of Biology Faculty of Science Utrecht University Padualaan 83584 CH Utrecht The Netherlands.
- 2017-09-15
Published in:
- Annals of clinical and translational neurology. - 2017
English
Paraneoplastic neurological syndromes (PNS) are often characterized by the presence of antineuronal antibodies in patient serum or cerebrospinal fluid. The detection of antineuronal antibodies has proven to be a useful tool in PNS diagnosis and the search for an underlying tumor. Here, we describe three patients with autoantibodies to several epitopes of the axon initial segment protein tripartite motif 46 (TRIM46). We show that anti-TRIM46 antibodies are easy to detect in routine immunohistochemistry screening and can be confirmed by western blotting and cell-based assay. Anti-TRIM46 antibodies can occur in patients with diverse neurological syndromes and are associated with small-cell lung carcinoma.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1002/acn3.396
- PMID 28904989
- Persistent URL
- https://sonar.ch/global/documents/261957
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