Prefrontal cortical control of a brainstem social behavior circuit.
- Franklin TB Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.
- Silva BA Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.
- Perova Z MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.
- Marrone L Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.
- Masferrer ME Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.
- Zhan Y Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.
- Kaplan A Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.
- Greetham L Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.
- Verrechia V Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.
- Halman A Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.
- Pagella S Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.
- Vyssotski AL Institute of Neuroinformatics, University of Zürich and Swiss Federal Institute of Technology (ETH), Zurich, Switzerland.
- Illarionova A Schaller Research Group on Neuropeptides, German Cancer Research Center DKFZ, Cell Network Cluster of Excellence, University of Heidelberg, Heidelberg, Germany.
- Grinevich V Schaller Research Group on Neuropeptides, German Cancer Research Center DKFZ, Cell Network Cluster of Excellence, University of Heidelberg, Heidelberg, Germany.
- Branco T MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.
- Gross CT Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy.
- 2017-01-10
Published in:
- Nature neuroscience. - 2017
Animals
Behavior, Animal
Brain Stem
Mice
Mice, Inbred C57BL
Models, Animal
Neural Pathways
Periaqueductal Gray
Prefrontal Cortex
Social Behavior
English
The prefrontal cortex helps adjust an organism's behavior to its environment. In particular, numerous studies have implicated the prefrontal cortex in the control of social behavior, but the neural circuits that mediate these effects remain unknown. Here we investigated behavioral adaptation to social defeat in mice and uncovered a critical contribution of neural projections from the medial prefrontal cortex to the dorsal periaqueductal gray, a brainstem area vital for defensive responses. Social defeat caused a weakening of functional connectivity between these two areas, and selective inhibition of these projections mimicked the behavioral effects of social defeat. These findings define a specific neural projection by which the prefrontal cortex can control and adapt social behavior.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1038/nn.4470
- PMID 28067904
- Persistent URL
- https://sonar.ch/global/documents/262528
Statistics
Document views: 40
File downloads:
- Full-text: 0