Journal article

Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017.

  • Hiemke C Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Mainz, Germany.
  • Bergemann N Kitzberg Hospitals, Center for Psychosomatic Medicine and Psychotherapy, Bad Mergentheim, Germany.
  • Clement HW Department of Child and Adolescent Psychiatry, University of Freiburg, Freiburg, Germany.
  • Conca A Servizio Psichiatrico del Comprensorio Sanitario di Bolzano, Bolzano, Italy.
  • Deckert J Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Würzburg, Germany.
  • Domschke K Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Eckermann G Psychiatric Hospital, Kaufbeuren, Germany.
  • Egberts K Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Germany.
  • Gerlach M Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Germany.
  • Greiner C Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany.
  • Gründer G Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, and JARA - Translational Brain Medicine, Aachen, Germany.
  • Haen E Clinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.
  • Havemann-Reinecke U Department of Psychiatry and Psychosomatics, University of Göttingen, Göttingen, Germany.
  • Hefner G Psychiatric Hospital, Vitos Klinik, Eichberg, Eltville, Germany.
  • Helmer R Center of Epilepsy, Bielefeld, Germany.
  • Janssen G Medical Laboratory Stein, Limbach Group, Mönchengladbach, Germany.
  • Jaquenoud E Psychiatric Hospital, Königsfelden, Brugg, Aargau, Switzerland.
  • Laux G Institute of Psychological Medicine, Haag in Oberbayern, Germany.
  • Messer T Danuviuskliniken, Psychiatric Hospital, Pfaffenhofen, Germany.
  • Mössner R Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
  • Müller MJ Psychiatric Hospitals Oberberggruppe, Berlin, Germany.
  • Paulzen M Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, and JARA - Translational Brain Medicine, Aachen, Germany.
  • Pfuhlmann B Psychiatric Hospital Weisser Hirsch, Dresden, Germany.
  • Riederer P Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Würzburg, Germany.
  • Saria A Experimental Psychiatry Unit, Department of Psychiatry 1, Medical University of Innsbruck, Innsbruck, Austria.
  • Schoppek B kbo-Isar-Amper Klinikum München-Ost, Psychiatric Hospital, Munich-Haar, Germany.
  • Schoretsanitis G Department of Psychiatry, University of Bern, Bern, Switzerland.
  • Schwarz M Department of Laboratory Medicine, Ludwig Maximilian University, Munich, Germany.
  • Gracia MS Clinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.
  • Stegmann B Clinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.
  • Steimer W Institute of Clinical Chemistry and Pathobiochemistry, Technical University Munich, Munich, Germany.
  • Stingl JC Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany.
  • Uhr M Max Planck Institute of Psychiatry, Munich, Germany.
  • Ulrich S Aristo Pharma GmbH, Berlin, Germany.
  • Unterecker S Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Würzburg, Germany.
  • Waschgler R Psychiatric Hospital, Feldkirch, Austria.
  • Zernig G Experimental Psychiatry Unit, Department of Psychiatry 1, Medical University of Innsbruck, Innsbruck, Austria.
  • Zurek G Medical Laboratory Bremen, Bremen, Germany.
  • Baumann P Department of Psychiatry, University of Lausanne, Prilly-Lausanne, Switzerland.
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  • 2017-09-15
Published in:
  • Pharmacopsychiatry. - 2018
English Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood to optimize pharmacotherapy. It considers the interindividual variability of pharmacokinetics and thus enables personalized pharmacotherapy. In psychiatry and neurology, patient populations that may particularly benefit from TDM are children and adolescents, pregnant women, elderly patients, individuals with intellectual disabilities, patients with substance abuse disorders, forensic psychiatric patients or patients with known or suspected pharmacokinetic abnormalities. Non-response at therapeutic doses, uncertain drug adherence, suboptimal tolerability, or pharmacokinetic drug-drug interactions are typical indications for TDM. However, the potential benefits of TDM to optimize pharmacotherapy can only be obtained if the method is adequately integrated in the clinical treatment process. To supply treating physicians and laboratories with valid information on TDM, the TDM task force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) issued their first guidelines for TDM in psychiatry in 2004. After an update in 2011, it was time for the next update. Following the new guidelines holds the potential to improve neuropsychopharmacotherapy, accelerate the recovery of many patients, and reduce health care costs.
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  • English
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https://sonar.ch/global/documents/263484
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