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Epitranscriptomics of cancer.
Journal article

Epitranscriptomics of cancer.

  • Tusup M Department of Dermatology, University Hospital of Zürich, Zurich 8091, Switzerland.
  • Kundig T Department of Dermatology, University Hospital of Zürich, Zurich 8091, Switzerland.
  • Pascolo S Department of Dermatology, University Hospital of Zürich, Zurich 8091, Switzerland.
  • 2018-06-15
Published in:
  • World journal of clinical oncology. - 2018
2’O-methylation or methylcytidine
5-methylcytidine
Inosine
N6-methyladenosine
Pseudouridine
RNA modifications
English The functional impact of modifications of cellular RNAs, including mRNAs, miRNAs and lncRNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported. Some RNA modifications promote, while others decrease the growth and invasiveness of cancer. The present manuscript reviews the current knowledge on the potential impacts of N6-Methyladenosine, Pseudouridine, Inosine, 2'O-methylation or methylcytidine in cancer's RNA. It also highlights the remaining questions and provides hints on research avenues and potential therapeutic applications, whereby modulating dynamic RNA modifications may be a new method to treat cancer.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/26466
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